User profiles for Brian A. McCool
Brian A. McCoolProfessor, Dept. Physiology & Pharmacology, Wake Forest School of Medicine Verified email at wakehealth.edu Cited by 4768 |
Substitution of a mutant α2a-adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing …
…, LB MacMillan, TZ Guo, BA McCool… - Proceedings of the …, 1997 - National Acad Sciences
Norepinephrine contributes to antinociceptive, sedative, and sympatholytic responses in
vivo, and α 2 adrenergic receptor (α 2 AR) agonists are used clinically to mimic these effects. …
vivo, and α 2 adrenergic receptor (α 2 AR) agonists are used clinically to mimic these effects. …
Chronic ethanol and withdrawal differentially modulate pre-and postsynaptic function at glutamatergic synapses in rat basolateral amygdala
…, A Chappell, DW DuBois, BA McCool - Journal of …, 2007 - journals.physiology.org
Withdrawal anxiety is a significant factor contributing to continued alcohol abuse in
alcoholics. This anxiety is long-lasting, can manifest well after the overt physical symptoms of …
alcoholics. This anxiety is long-lasting, can manifest well after the overt physical symptoms of …
Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3
DM Lovinger, BA McCOOL - Journal of neurophysiology, 1995 - journals.physiology.org
1. The pharmacology of the metabotropic glutamate receptor (mGluR) that mediates synaptic
depression at corticostriatal synapses was investigated with the use of field potential and …
depression at corticostriatal synapses was investigated with the use of field potential and …
Early social isolation in male Long‐Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self‐administration
BA McCool, AM Chappell - Alcoholism: Clinical and …, 2009 - Wiley Online Library
Background: Postweaning social isolation in rats produces profound and long‐lasting
cognitive and behavioral deficits in adult animals. Importantly, this housing manipulation alters …
cognitive and behavioral deficits in adult animals. Importantly, this housing manipulation alters …
Nonhuman primate parthenogenetic stem cells
Parthenogenesis is the biological phenomenon by which embryonic development is initiated
without male contribution. Whereas parthenogenesis is a common mode of reproduction in …
without male contribution. Whereas parthenogenesis is a common mode of reproduction in …
Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens
Background: Chronic ethanol exposure reduces dopamine transmission in the nucleus
accumbens, which may contribute to the negative affective symptoms associated with ethanol …
accumbens, which may contribute to the negative affective symptoms associated with ethanol …
Adolescent rearing conditions influence the relationship between initial anxiety‐like behavior and ethanol drinking in male Long Evans rats
AM Chappell, E Carter, BA McCool… - Alcoholism: Clinical …, 2013 - Wiley Online Library
Background Rodent studies have demonstrated that adolescent social isolation results in
many behavioral perturbations, including increases in anxiety‐like behaviors. Socially isolated …
many behavioral perturbations, including increases in anxiety‐like behaviors. Socially isolated …
Reverse osmosis desalting of inland brackish water of high gypsum scaling propensity: kinetics and mitigation of membrane mineral scaling
A Rahardianto, BC McCool… - Environmental science & …, 2008 - ACS Publications
The potential for mineral scaling that may limit the generation of new potable water resources
by reverse osmosis (RO), from inland brackish water of high gypsum scaling propensity, …
by reverse osmosis (RO), from inland brackish water of high gypsum scaling propensity, …
Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons
DW Floyd, KY Jung, BA McCool - Journal of Pharmacology and …, 2003 - ASPET
Withdrawal anxiety after chronic alcohol is likely to contribute to drug seeking and relapse in
alcoholics. The brain regions regulating fear/anxiety behaviors, especially neurotransmitter …
alcoholics. The brain regions regulating fear/anxiety behaviors, especially neurotransmitter …
Ethanol modulation of synaptic plasticity
BA McCool - Neuropharmacology, 2011 - Elsevier
Synaptic plasticity in the most general terms represents the flexibility of neurotransmission
in response to neuronal activity. Synaptic plasticity is essential both for the moment-by-…
in response to neuronal activity. Synaptic plasticity is essential both for the moment-by-…