Addiction is continued drug use despite its harm. As one always has alternatives, addiction
can be construed as a decision to allocate behavior to drug use. While decision making is …

Preclinical studies have documented that serotonin (5-HT) can modulate the behavioral
effects of cocaine. The present study examined the ability of 5-HT to attenuate the reinforcing …

The aging brain is characterized by progressive increases in neuroinflammation and central
insulin resistance, which contribute to neurodegenerative diseases and cognitive …

Background: Recent cannabis use is associated with an approximate two-fold increase in
automobile crash risk, but detecting cannabis-impaired driving remains a challenge. …

Products containing naphthalen-1-yl-(1-pentylindol-3-yl) methanone (JWH-018) and
naphthalen-1-yl-(1-butylindol-3-yl) methanone (JWH-073) are emerging drugs of abuse. Here, the …

The recreational use of synthetic cannabinoids has recently increased. This increase is due,
in part, to the recent availability of inexpensive compound sold legally online in bulk. In …

Addiction may be viewed as choice governed by competing contingencies. One factor
impacting choice, particularly as it relates to addiction, is sensitivity to delayed rewards. …

Synthetic cannabinoids (CBs) [naphthalen-1-yl-(1-pentylindol-3-yl) methanone (JWH-018)
and naphthalen-1-yl-(1-butylindol-3-yl) methanone (JWH-073)] are marketed, sold, and used …

Rationale A variety of behavioral procedures have been developed to assess cannabinoid
activity in mice; however, the feasibility of establishing Δ 9 -THC as a discriminative stimulus …

In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross,
the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, …