Combining antigen and immunomodulators: Emerging trends in antigen-specific immunotherapy for autoimmunity

L Northrup, MA Christopher, BP Sullivan… - Advanced drug delivery …, 2016 - Elsevier
A majority of current therapies for autoimmune diseases are general immunosuppressants,
which can compromise patient response to opportunistic infection and lead to adverse events…

Hepatocyte tissue factor activates the coagulation cascade in mice

BP Sullivan, AK Kopec, N Joshi, H Cline… - Blood, The Journal …, 2013 - ashpublications.org
In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs)
and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) …

Fibrin (ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12

…, H Cline-Fedewa, AV Wojcicki, JL Ray, BP Sullivan… - Journal of …, 2017 - Elsevier
Background & Aims Acetaminophen (APAP)-induced liver injury is coupled with activation of
the blood coagulation cascade and fibrin(ogen) accumulation within APAP-injured livers of …

[HTML][HTML] The coagulation system contributes to αVβ6 integrin expression and liver fibrosis induced by cholestasis

BP Sullivan, PH Weinreb, SM Violette… - The American journal of …, 2010 - Elsevier
Chronic injury to intrahepatic bile duct epithelial cells (BDECs) elicits expression of various
mediators, including the αVβ6 integrin, promoting liver fibrosis. We tested the hypothesis that …

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice

K Miyakawa, N Joshi, BP Sullivan… - Blood, The Journal …, 2015 - ashpublications.org
Acetaminophen (APAP)-induced liver injury in humans is associated with robust coagulation
cascade activation and thrombocytopenia. However, it is not known whether coagulation-…

Thrombin Inhibition with Dabigatran Protects against High-Fat Diet–Induced Fatty Liver Disease in Mice

…, N Joshi, KL Towery, KM Kassel, BP Sullivan… - … of Pharmacology and …, 2014 - ASPET
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic
syndrome. Robust coagulation cascade activation is common in obese patients with …

[HTML][HTML] Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet

…, AP Owens III, CE Rockwell, BP Sullivan… - The American journal of …, 2011 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and
metabolic syndrome and contributes to increased risk of cardiovascular disease and liver-related …

Multivalent nanomaterials: learning from vaccines and progressing to antigen-specific immunotherapies

BL Hartwell, L Antunez, BP Sullivan, S Thati… - Journal of …, 2015 - Elsevier
Continued development of multivalent nanomaterials has provided opportunities for the
advancement of antigen-specific immunotherapies. New insights emerge when considering the …

[HTML][HTML] Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental autoimmune …

JO Sestak, BP Sullivan, S Thati, L Northrup… - … Therapy-Methods & …, 2014 - cell.com
Autoimmune diseases such as multiple sclerosis (MS) are typified by the misrecognition of
self-antigen and the clonal expansion of autoreactive T cells. Antigen-specific …

[HTML][HTML] Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice

JP Luyendyk, BP Sullivan, GL Guo, R Wang - The American journal of …, 2010 - Elsevier
Altered hepatic lipid homeostasis, hepatocellular injury, and inflammation are features of
nonalcoholic steatohepatitis, which contributes significantly to liver-related morbidity and …