Imidazopyrimidines, potent inhibitors of p38 MAP kinase

…, DE Cavender, GC Olini, B Fahmy… - Bioorganic & medicinal …, 2003 - Elsevier
The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-α and
IL-1β. Inhibition of cytokine release may be a useful treatment for inflammatory conditions …

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

…, PH Schafer, EA Malloy, W Wu, B Fahmy… - … of Pharmacology and …, 1999 - ASPET
Tumor necrosis factor-α (TNF-α), a cytokine secreted by activated monocytes/macrophages
and T lymphocytes, has been implicated in several disease states, including rheumatoid …

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354):  A Potent and Selective p38 Kinase Inhibitor

…, SA Wadsworth, DE Cavender, B Fahmy… - Journal of medicinal …, 1998 - ACS Publications
Introduction. Chronic inflammatory diseases such as rheumatoid arthritis (RA), inflammatory
bowel disease (IBD), and psoriasis affect millions of people worldwide. Current drugs treat …

Inhibitors of unactivated p38 MAP kinase

…, K Averill, D Carter, D Cavender, B Fahmy… - Bioorganic & medicinal …, 2006 - Elsevier
Inhibition of the p38 map kinase pathway has been shown to be beneficial in the treatment
of inflammatory diseases. The first class of potent p38 kinase inhibitors was the …

Identification of anti-CD3 antibodies that do not modulate antigen but induce mitogenesis and block the mixed lymphocyte reaction

PE Rao, W Newman, E Meyer, B Fahmy, MA Talle… - Human immunology, 1992 - Elsevier
Using a panel of anti-CD3-TCR monoclonal antibodies (OKT3 AE), it appears possible to
separate the ability to cause surface antigen modulation from inhibition of MLR or induction of …

Induction of T-Cell Differentiation In Vitro by Thymin, a Purified Polypeptide Hormone of the Thymus

RS Basch, G Goldstein - Proceedings of the National …, 1974 - National Acad Sciences
Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the
expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (θ)] when …

Hematopoietic thymocyte precursors: IV. Enrichment of the precursors and evidence for heterogeneity.

RS Basch, JL Kadish, G Goldstein - The Journal of experimental …, 1978 - rupress.org
A method has been developed for the enrichment of the hematopoietic precursors of thymocytes
from spleen and bone marrow cells. Up to 40-fold enrichments were obtained resulting …

Hematopoietic thymocyte precursors

RS BASCH, JL KADISH, G GOLDSTEINII - J. Exp. Med, 1978 - ncbi.nlm.nih.gov
A method has been developed for the enrichment of the hematopoietic precursors of thymocytes
from spleen and bone marrow cells. Up to 40-fold enrichments were obtained resulting …

Thymopoietin enhances the allogeneic response and cyclic GMP levels of mouse peripheral, thymus-derived lymphocytes

GH Sunshine, RS Basch, RG Coffey… - The Journal of …, 1978 - journals.aai.org
The action of the purified thymic factor, thymopoietin, on populations of post-thymic
lymphocytes has been studied. Thymopoietin, at concentrations as low as 1.5 ng/ml, uniquely …

Kinetics of small molecule inhibitor binding to p38 kinase

RL Thurmond, SA Wadsworth… - European journal of …, 2001 - Wiley Online Library
… The authors would like to thank Bohumila Fahmy for her technical assistance and Lars
Karlsson, Anders Brunmark, Frank Brown, and Victoria Rigg for their critical reading of the …