Rationale Citalopram is a racemate consisting of a 1:1 mixture of the R(−)- and S(+)-enantiomers.
Non-clinical studies show that the serotonin reuptake inhibitory activity of citalopram is …

The enantiomers of the potent non-competitive NMDA receptor antagonist ketamine and its
major metabolite, norketamine were evaluated as NMDA receptor antagonists using the rat …

The opiate agonists, ketobemidone, methadone and pethidine, were evaluated as N-methyl-d-aspartate
(NMDA) receptor antagonists using the rat cortical wedge preparation and the …

Several groups have characterized the pharmacology of α 4 - or α 6 β 3 δ-containing GABA
A receptors expressed in different cell systems. We have previously demonstrated that the …

Chronic insomnia affects a significant proportion of young adult and elderly populations.
Treatment strategies should alleviate nighttime symptoms, the feeling of nonrestorative sleep, …

The monoaminergic network, including serotonin (5-HT), norepinephrine (NE), and dopamine
(DA) pathways, is highly interconnected and has a well-established role in mood disorders…

Much evidence points to the involvement of N-methyl-d-aspartate (NMDA) receptors in the
development and maintainance of neuropathic pain. In neuropathic pain, there is generally …

The activation characteristics of synaptic and extrasynaptic GABA A receptors are important
for shaping the profile of phasic and tonic inhibition in the central nervous system, which will …

Vortioxetine (Lu AA21004) is an investigational novel antidepressant with multimodal activity
that functions as a 5-HT 3 , 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor …

GABA A receptors (GABA A Rs) are usually formed by α, β, and γ or δ subunits. Recently, δ-containing
GABA A Rs expressed in Xenopus oocytes were found to be sensitive to low …