Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity

…, M Nakane, P Jacobson, BC Lane - Journal of medicinal …, 2001 - ACS Publications
A novel class of functional ligands for the human glucocorticoid receptor is described. Substituents
in the C-10 position of the tetracyclic core are essential for glucocorticoid receptor (GR…

Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2, 5-dihydro-10-methoxy-2, 2 …

…, PB Jacobson, DM Wilcox, BC Lane - Journal of medicinal …, 2001 - ACS Publications
The preparation and characterization of a series of selective glucocorticoid receptor
modulators are described. The preliminary structure−activity relationship of nonaromatic C-5 …

Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2, 5-dihydro-2, 2, 4-trimethyl-1H …

…, DM Wilcox, P Nguyen, BC Lane - Journal of medicinal …, 2003 - ACS Publications
The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
as a novel class of selective ligands for the …

Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes

…, A Cherrington, S Efendic, BC Lane… - … of Pharmacology and …, 2005 - ASPET
Glucocorticoids amplify endogenous glucose production in type 2 diabetes by increasing
hepatic glucose output. Systemic glucocorticoid blockade lowers glucose levels in type 2 …

Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues

M Kawai, BC Lane, GC Hsieh, KW Mollison, GW Carter… - FEBS letters, 1993 - Elsevier
The immunosuppressive agent FK-506 has received much attention due to its efficacy and
potency in the areas of transplant rejection and autoimmune disease. Calcineurin, a Ca 2+ -…

Rapamycin analogs with reduced systemic exposure

…, N Tu, PE Wiedeman, Y Or, JR Luly, BC Lane… - Bioorganic & medicinal …, 2005 - Elsevier
… One can observe that in rats (Table 3), compounds 3 and 6 both have dramatically
shorter half-lives than rapamycin (1), as well as lower C max and AUC values upon a single …

Induction of selective biological responses to chemoattractants in a human monocyte-like cell line

GE Kay, BC Lane, R Snyderman - Infection and immunity, 1983 - Am Soc Microbiol
The availability of monocyte cell lines that can be induced to differentiate in a predictable
fashion can provide important tools for the study of the biochemical mechanisms of specific …

[HTML][HTML] A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases

…, ML Smith, M Pong, NM Nikolaidis, BC Lane… - Journal of investigative …, 1999 - Elsevier
T lymphocytes play a critical part in inflammatory skin diseases but are targeted by available
therapies that have only partial efficacy, significant side-effects, or both. Because psoriasis, …

Structural evidence for distinct IgG subclass-specific Fc receptors on mouse peritoneal macrophages

BC Lane, J Kan-Mitchell, MS Mitchell… - The Journal of …, 1980 - rupress.org
Membrane proteins which selectively bind to the Fc portion of IgG were identified in the
Nonidet P-40 extracts of radiolabeled thioglycollate- elicited mouse peritoneal macrophages. …

Fc receptors of mouse cell lines. I. Distinct proteins mediate the IgG subclass-specific Fc binding activities of macrophages.

BC Lane, SM Cooper - Journal of immunology (Baltimore, Md.: 1950 …, 1982 - journals.aai.org
To determine the biochemical basis for the two distinct IgG subclass binding specificities on
mouse macrophage-like cell lines, Fc-binding proteins were isolated from P388D1 and J774 …