Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
…, JC Jerman, AJ Stevens, D Smart, B Sargent… - Bioorganic & medicinal …, 2006 - Elsevier
Small molecule antagonists of the vanilloid receptor TRPV1 (also known as VR1) are
disclosed. Pyrrolidinyl ureas such as 8 and 15 (SB-705498) emerged as lead compounds …
disclosed. Pyrrolidinyl ureas such as 8 and 15 (SB-705498) emerged as lead compounds …
Investigation into the role of P2X3/P2X2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study
…, SG Summerfield, BS Sargent… - British journal of …, 2006 - Wiley Online Library
1 Two P2X 3 /P2X 2/3 receptor antagonists with different potencies were profiled
electrophysiologically in a rat model of nerve injury. 2 A‐317491 has poor CNS penetrance (blood : …
electrophysiologically in a rat model of nerve injury. 2 A‐317491 has poor CNS penetrance (blood : …
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced …
…, S Ociepka, A Ray, CM Regan, B Sargent… - Biochemical …, 2007 - Elsevier
GSK207040 (5-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-2-pyrazinecarboxamide)
and GSK334429 (1-(1-methylethyl)-4-({1-[6-(trifluoromethyl)-3-pyridinyl]-4…
and GSK334429 (1-(1-methylethyl)-4-({1-[6-(trifluoromethyl)-3-pyridinyl]-4…
Use of dynamic weight bearing as a novel end-point for the assessment of Freund's Complete Adjuvant induced hypersensitivity in mice
I Robinson, B Sargent, JP Hatcher - Neuroscience letters, 2012 - Elsevier
Animal models are an integral part of pain research. However, current models tend to rely on
evoked responses and there is a belief that non-evoked responses may be a more relevant …
evoked responses and there is a belief that non-evoked responses may be a more relevant …
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl) phenyl]-pyrazolo [1, 5-b] pyridazine] is effective in animal models of …
…, G Murkitt, A Naylor, E Pickup, B Sargent… - … of Pharmacology and …, 2005 - ASPET
The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively
present in the spinal cord and has been implicated in chronic pain states in rat and man. A …
present in the spinal cord and has been implicated in chronic pain states in rat and man. A …
Artemin–GFRα3 interactions partially contribute to acute inflammatory hypersensitivity
P Thornton, JP Hatcher, I Robinson, B Sargent… - Neuroscience …, 2013 - Elsevier
The expression of artemin (ARTN), a glial cell line-derived neurotrophic factor (GDNF) family
ligand, increases in pre-clinical models of nociception and recent evidence suggests this …
ligand, increases in pre-clinical models of nociception and recent evidence suggests this …
[CITATION][C] The cyclo-oxygenase 2 inhibitor, GW406381 is effective in animal models of neuropathic pain and central sensitisation
…, G Murkitt, A Naylor, E Pickup, B Sargent… - … of Pharmacology and …, 2004 - ASPET
The pathogenic form of the cyclo-oxygenase (COX) enzyme, COX-2, is also constitutively
present in the spinal cord and has been implicated in chronic pain states in rat and man. A …
present in the spinal cord and has been implicated in chronic pain states in rat and man. A …
Homeosterically related plant growth regulators. II. Biological assay studies
DR Sargent, B De la Houssaye, SR Bryant… - Journal of agricultural …, 1973 - ACS Publications
-OCH2 (D,-NHCH2GI),-CH2CH2 (III), or-S (IV), and their effects on elongation, as well as
protein and carbohydrate composition of the treated segments, were determined. Derivatives in …
protein and carbohydrate composition of the treated segments, were determined. Derivatives in …
[CITATION][C] Available online at www. sciencedirect. com
…, D Hu, H Nodera, SB Rutkove, I Robinson, B Sargent… - Neuroscience Letters, 2012
[CITATION][C] Screening for MRSA vs. Not Screening on Admission
A Ballard, N Crawford, L Miller, B Sargent