Inward rectifier K + channels pass prominent inward currents, while outward currents are
largely blocked. The inward rectification is due to block by intracellular Mg 2+ and a Mg 2+ -…

Arsenic trioxide (As 2 O 3 ) produces dramatic remissions in patients with relapsed or refractory
acute promyelocytic leukemia. Its clinical use is burdened by QT prolongation, torsade …

The diamidine pentamidine is used to treat leishmaniasis, trypanosomiasis, and Pneumocystis
carinii pneumonia. Treatment may be accompanied by prolongation of the QT interval of …

INWARDLY rectifying K + channels (IRKs) conduct current preferentially in the inward
direction. This inward rectification has two components: voltage-dependent blockade by …

INTRODUCTION: Direct block of I Kr by non-antiarrhythmic drugs (NARDs) is a major cause
of QT prolongation and torsades de pointes (TdP), and has made the hERG potassium …

Voltage‐gated potassium channels, Kv1.1, Kv1.2 and Kv1.6, were identified as PCR products
from mRNA prepared from nodose ganglia. Immunocytochemical studies demonstrated …

Direct block of the cardiac potassium channel human ether-a-go-go-related gene (hERG)
by a large, structurally diverse group of therapeutic compounds causes drug-induced QT …

Hereditary long QT syndrome (hLQTS) is a heterogeneous genetic disease characterized
by prolonged QT interval in the electrocardiogram, recurrent syncope, and sudden cardiac …

We report the cloning and functional expression of a novel K + channel β-subunit from human
atrium, hKvβ3. hKvβ3 is highly homologous to the two β-subunits cloned from rat brain, …

Voltage-gated K + (Kv) channels are important in the physiology of both excitable and
nonexcitable cells. The diversity in Kv currents is reflected in multiple Kv channel genes whose …