Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that
have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. …
have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. …
Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway
J Seubert, B Yang, JA Bradbury, J Graves… - Circulation …, 2004 - Am Heart Assoc
Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic
acids (EETs); however, the functional role of this P450 and its eicosanoid products in the …
acids (EETs); however, the functional role of this P450 and its eicosanoid products in the …
Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas
D Li, B Yang, JL Mehta - American Journal of Physiology …, 1998 - journals.physiology.org
Oxidized low-density lipoprotein (ox-LDL) plays a critical role in the development of
atherosclerosis. Recent studies show that ox-LDL may induce apoptosis of cultured rabbit smooth …
atherosclerosis. Recent studies show that ox-LDL may induce apoptosis of cultured rabbit smooth …
Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and …
L Chen, WH Haught, B Yang, TGP Saldeen… - Journal of the American …, 1997 - jacc.org
Objectives. We sought to document the common mechanisms of the antiatherogenic effects
of the cholesterol-lowering hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase …
of the cholesterol-lowering hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase …
Inhibition of arterial thrombus formation by ApoA1 Milano
D Li, S Weng, B Yang, DS Zander… - … , and vascular biology, 1999 - Am Heart Assoc
The mutant form of human apoA1, known as apoA1 Milano, is formed as a result of arginine
173 to cysteine substitution and inhibits experimental atherosclerosis in cholesterol-fed …
173 to cysteine substitution and inhibits experimental atherosclerosis in cholesterol-fed …
Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits
BC Yang, MI Phillips, D Mohuczy, H Meng… - … , and vascular biology, 1998 - Am Heart Assoc
Angiotensin II (Ang II) promotes vascular smooth muscle growth and may be involved in the
initiation and progression of atherosclerosis. To examine whether Ang II receptor expression …
initiation and progression of atherosclerosis. To examine whether Ang II receptor expression …
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells
B Yang, LR Graham, S Dikalov, RP Mason… - Molecular …, 2001 - ASPET
CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic
acids (EETs), have potent vasodilatory, antiinflammatory and cardioprotective …
acids (EETs), have potent vasodilatory, antiinflammatory and cardioprotective …
Proapoptotic effects of ANG II in human coronary artery endothelial cells: role of AT1receptor and PKC activation
D Li, B Yang, MI Philips… - American Journal of …, 1999 - journals.physiology.org
Anoxia-reoxygenation, tumor necrosis factor-α (TNF-α), and angiotensin II (ANG II) have been
shown to induce apoptosis in myocytes. However, the role of these mediators in causing …
shown to induce apoptosis in myocytes. However, the role of these mediators in causing …
[HTML][HTML] Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective
…, CX Li, M Saulnier, N Simpson, B Yang - Nature Reviews Drug …, 2015 - nature.com
Discussion section• Biological significance of findings• How potency of off-target activity
compares with that of the intended target• Relative in vitropotency for off-target activity versus …
compares with that of the intended target• Relative in vitropotency for off-target activity versus …
Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats
K Engström, AS Saldeen, B Yang… - Upsala Journal of …, 2009 - Taylor & Francis
Background. The interest in n-3 polyunsaturated fatty acids (PUFAs) has expanded significantly
in the last few years, due to their many positive effects described. Consequently, the …
in the last few years, due to their many positive effects described. Consequently, the …