User profiles for B. P. Imbimbo
Bruno P. ImbimboChiesi Farmaceutici Verified email at chiesi.com Cited by 14404 |
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …
Late-life depression, mild cognitive impairment, and dementia: possible continuum?
…, A D'Introno, AM Colacicco, BP Imbimbo… - The American Journal of …, 2010 - Elsevier
Clinical and epidemiologic research has focused on the identification of risk factors that may
be modified in predementia syndromes, at a preclinical and early clinical stage of …
be modified in predementia syndromes, at a preclinical and early clinical stage of …
Diet and Alzheimer's disease risk factors or prevention: the current evidence
… Any decrease in inflammation (via weight loss or improved regulation of glucose and
blood pressure) may subsequently reduce the risk for cognitive decline (Figure 1) Citation[103]. …
blood pressure) may subsequently reduce the risk for cognitive decline (Figure 1) Citation[103]. …
[HTML][HTML] The β-secretase BACE1 in Alzheimer's disease
…, A De Vos, R Nisticò, M Corbo, BP Imbimbo… - Biological …, 2021 - Elsevier
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), …
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), …
Relationships of dietary patterns, foods, and micro-and macronutrients with Alzheimer's disease and late-life cognitive disorders: a systematic review
…, M Lozupone, BP Imbimbo… - Journal of …, 2017 - content.iospress.com
In the last decade, the association between diet and cognitive function or dementia has
been largely investigated. In the present article, we systematically reviewed observational …
been largely investigated. In the present article, we systematically reviewed observational …
[HTML][HTML] Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?
Several epidemiological studies suggest that long-term use of non-steroidal anti-inflammatory
drugs (NSAIDs) may protect subjects carrying one or more ε4 allele of the apolipoprotein …
drugs (NSAIDs) may protect subjects carrying one or more ε4 allele of the apolipoprotein …
Colonic mass movements in idiopathic chronic constipation.
G Bassotti, M Gaburri, BP Imbimbo, L Rossi, F Farroni… - Gut, 1988 - gut.bmj.com
As relatively little is known of human colonic motor activity either in health, or in pathological
conditions, we investigated mass movements in 14 chronically constipated patients and 18 …
conditions, we investigated mass movements in 14 chronically constipated patients and 18 …
[HTML][HTML] A path toward precision medicine for neuroinflammatory mechanisms in Alzheimer's disease
…, A Lucía, M Watling, BP Imbimbo… - Frontiers in …, 2020 - frontiersin.org
Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum. …
represents one of the earliest pathomechanistic alterations throughout the AD continuum. …
Nutraceutical properties of Mediterranean diet and cognitive decline: possible underlying mechanisms
Recent prospective studies provided evidence that higher adherence to a Mediterranean-type
diet could be associated with slower cognitive decline, reduced risk of progression from …
diet could be associated with slower cognitive decline, reduced risk of progression from …
Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms
…, V Frisardi, C Capurso, BP Imbimbo… - Journal of …, 2010 - content.iospress.com
… dementia and cognitive decline included high blood pressure (BP) and hypertension, total …
impaired glucose metabolism, dyslipidemia, and high BP and that depicts a risk status for both …
impaired glucose metabolism, dyslipidemia, and high BP and that depicts a risk status for both …