Leukotriene B 4 (LTB 4 ) is a pro-inflammatory mediator that has been implicated in the
pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. …

Dopamine (DA) and the dopaminergic agonists n-propylnorapomorphine (NPA), 2-amino-6,7-dihydroxytetrahydronaphthalene
(ADTN) and apomorphine (APO) inhibit forskolin-…

Two large-scale methods based primarily on the use of procainamide-Sepharose gels were
developed for the purification of horse and human serum non-specific cholinesterases. With …

Quantitative analysis of radioligand binding to the porcine anterior pituitary dopaminergic
receptor indicates the existence of two affinity states of the same receptor population. Biphasic …

A series of 2-phenyl-3H-imidazo [4, 5-6] pyridine-3-acetamides were designed and synthesized
as non-benzodiazepine anxiolytics based on a molecular disconnection of a typical 1, 4-…

Nuclear factor kappa B (NF-κB) is a ubiquitous, inducible transcription factor that regulates
the initiation and progression of immune and inflammatory stress responses. NF-κB activation …

The enantiomers of 2-[2-(dimethylamino) ethyl]-3, 4-dihydro-4-methylpyrido [3, 2-/]-l, 4-oxazapine-5
(2H)-thione (rocastine) and two of its more potent analogues were prepared with an …

Four new clerodane diterpenes, casearinols A and B (1 and 2) and casearinones A and B (3
and 4), were isolated from the leaves of Casearia guianensis. These immunomodulatory …

Long-term exposure of various cell types to β-adrenergic agonists such as isoproterenol
leads to an attenuated responsiveness ("desensitization") of the adenylate cyclase system to …

Dopamine receptors, solubilized from bovine anterior pituitary membranes with the detergent
digitonin, retained a typical dopaminergic specificity for the binding of both agonists and …