User profiles for Avner Schlessinger

Avner Schlessinger

Professor, Icahn School of Medicine at Mount Sinai, New York, NY
Verified email at mssm.edu
Cited by 8851

PredictProtein-predicting protein structure and function for 29 years

…, C Sander, A Schafferhans, A Schlessinger… - Nucleic acids …, 2021 - academic.oup.com
Since 1992 PredictProtein ( https://predictprotein.org ) is a one-stop online resource for
protein sequence analysis with its main site hosted at the Luxembourg Centre for Systems …

[PDF][PDF] Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder

…, S Esharif, T Ben-Omran, M Topcu, A Schlessinger… - Cell, 2016 - cell.com
Autism spectrum disorders (ASD) are a group of genetic disorders often overlapping with
other neurological conditions. We previously described abnormalities in the branched-chain …

Crystal structure of a eukaryotic phosphate transporter

…, AJ Risenmay, Z Roe-Zurz, BH Chau, A Schlessinger… - Nature, 2013 - nature.com
Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid
synthesis, signalling and chemical energy storage. Proton-coupled transporters of the major …

PredictProtein—an open resource for online prediction of protein structural and functional features

…, H Ashkenazy, M Punta, A Schlessinger… - Nucleic acids …, 2014 - academic.oup.com
PredictProtein is a meta-service for sequence analysis that has been predicting structural
and functional features of proteins since 1992. Queried with a protein sequence it returns: …

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin

L Chen, B Pawlikowski, A Schlessinger… - Pharmacogenetics …, 2010 - journals.lww.com
Objectives The goals of this study were to determine the role of organic cation transporter 3 (OCT3)
in the pharmacological action of metformin and to identify and functionally …

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling

…, A Kernytsky, A Schlessinger… - Proteins: Structure …, 2003 - Wiley Online Library
We participated in the fold recognition and homology sections of CASP5 using primarily in‐house
software. The central feature of our structure prediction strategy involved the ability to …

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

…, V Setola, JJ Irwin, H Fan, A Schlessinger… - Nature chemical …, 2011 - nature.com
G protein–coupled receptors (GPCRs) are intensely studied as drug targets and for their
role in signaling. With the determination of the first crystal structures, interest in structure-based …

ModBase, a database of annotated comparative protein structure models, and associated resources

…, D Schneidman-Duhovny, A Schlessinger… - Nucleic acids …, 2010 - academic.oup.com
ModBase ( http://salilab.org/modbase ) is a database of annotated comparative protein
structure models. The models are calculated by ModPipe, an automated modeling pipeline that …

Towards a consensus on datasets and evaluation metrics for developing B‐cell epitope prediction tools

…, EL Roggen, A Sette, A Schlessinger… - Journal of Molecular …, 2007 - Wiley Online Library
AB‐cell epitope is the three‐dimensional structure within an antigen that can be bound to
the variable region of an antibody. The prediction of B‐cell epitopes is highly desirable for …

Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions

S Vatansever, A Schlessinger, D Wacker… - Medicinal research …, 2021 - Wiley Online Library
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …