Beyond providing evolutionary advantages, venoms offer unique research tools, as they were
developed to target functionally important proteins and pathways. As a key pain receptor …

Chronic pain is a major medical issue which reduces the quality of life of millions and inflicts
a significant burden on health authorities worldwide. Currently, management of chronic pain …

The receptor channel TRPV1 (Transient Receptor Potential Vanilloid 1) is expressed by
primary afferent sensory neurons of the pain pathway, where it functions as a sensor of noxious …

Altered glucose reabsorption via the facilitative glucose transporter 2 (GLUT2) during diabetes
may lead to renal proximal tubule cell (RPTC) injury, inflammation, and interstitial fibrosis. …

Ivermectin (IVM), a widely used antiparasitic agent in human and veterinary medicine, was
recently shown to augment macroscopic currents through rat P2X 4 receptor channels (Khakh…

Many neurotoxins inflict pain by targeting receptors expressed on nociceptors, such as the
polymodal cationic channel TRPV1. The tarantula double-knot toxin (DkTx) is a peptide with …

Toxins have evolved to target regions of membrane ion channels that underlie ligand binding,
gating, or ion permeation, and have thus served as invaluable tools for probing channel …

The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic
transmission and critically contribute to synaptic plasticity in the brain, hence the existence of …

Airway ciliated cells express an ATP‐gated P2X receptor channel of unknown subunit
composition (P2X cilia ) which is modulated by Na + and by long exposures to ATP. P2X cilia was …

Polymorphism in TCF7L2, a component of the canonical Wnt signaling pathway, has a strong
association with β-cell dysfunction and type 2 diabetes through a mechanism that has yet …