Different effects of St John's wort on the pharmacokinetics of simvastatin and pravastatin

…, S Tsuruoka, K Nishiki, A Kawaguchi… - Clinical …, 2001 - Wiley Online Library
Objective St John's Wort, a widely used herbal product, is an inducer of CYP3A4 and it
decreases blood concentrations of CYP3A4 substrates. The effects of St John's Wort on the …

Amiselimod, a novel sphingosine 1‐phosphate receptor‐1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

…, T Harada, P Ni, S Inoue, A Kawaguchi - British Journal of …, 2017 - Wiley Online Library
Background and Purpose We conducted preclinical and clinical studies to examine the
pharmacological, particularly cardiac, effects of amiselimod (MT‐1303), a second‐generation …

Bioactive constituents of chinese natural medicines. VI. Moutan cortex.(2): structures and radical scavenging effects of suffruticosides A, B, C, D, and E and galloyl …

H Matsuda, T Ohta, A Kawaguchi… - Chemical and …, 2001 - jstage.jst.go.jp
Radical Scavenging Effect on DPPH Radical The methanol-eluted fraction of the water-soluble
portion from Chinese Moutan Cortex showed a scavenging effect on DPPH radical (SC50 …

Galloyl-oxypaeoniflorin, suffruticosides A, B, C, and D, five new antioxidative glycosides, and suffruticoside E, A paeonol glycoside, from Chinese moutan cortex

M Yoshikawa, E Uchida, A Kawaguchi… - Chemical and …, 1992 - jstage.jst.go.jp
Five new antioxidative glycosides named galloyl-oxypaeoniflorin, suffruticosides A, B, C, and
D, and a new paeonol glycoside named suffruticoside E have been isolated from Chinese …

Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans

…, S Kinoshita, BP Madera, D Gunput, A Kawaguchi… - Xenobiotica, 2014 - Taylor & Francis
The absorption, metabolism and excretion of teneligliptin were investigated in healthy male
subjects after a single oral dose of 20 mg [ 14 C]teneligliptin. 2. Total plasma radioactivity …

Drug interaction between St John's Wort and quazepam

A Kawaguchi, M Ohmori, S Tsuruoka… - British journal of …, 2004 - Wiley Online Library
Aim St John's Wort (SJW) enhances CYP3A4 activity and decreases blood concentrations
of CYP3A4 substrates. In this study, the effects of SJW on a benzodiazepine hypnotic, …

A Ka-Band SATCOM Transceiver in 65-nm CMOS With High-Linearity TX and Dual-Channel Wide-Dynamic-Range RX for Terrestrial Terminal

…, AA Fadila, T Someya, A Kawaguchi… - IEEE Journal of Solid …, 2021 - ieeexplore.ieee.org
In this article, a $Ka$ -band satellite communication (SATCOM) transceiver is first presented
using a standard CMOS technology. The proposed $Ka$ -band SATCOM transceiver …

Phase 1 studies to define the safety, tolerability, and pharmacokinetic and pharmacodynamic profiles of the nonsteroidal mineralocorticoid receptor antagonist …

T Nakamura, A Kawaguchi - Clinical Pharmacology in Drug …, 2021 - Wiley Online Library
Apararenone is a long‐acting, nonsteroidal mineralocorticoid receptor antagonist (MRA). The
safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles of single…

Vitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure

S Tsuruoka, A Kawaguchi, K Nishiki… - American journal of …, 2002 - Elsevier
We evaluated the biocompatibility of a newly developed vitamin E hemodialyzer (CL-EE;
Terumo Co Ltd, Tokyo, Japan) by neutrophil function and oxidant stress in patients with end-…

Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex.(1): Absolute stereostructures of two monoterpenes …

M Yoshikawa, T Ohta, A Kawaguchi… - Chemical and …, 2000 - jstage.jst.go.jp
The methanolic extract and the ethyl acetate-soluble and methanol-eluted fractions from
Chinese Moutan Cortex, the roots of Paeonia suffruticosa ANDREWS, were found to exhibit …