Mammals detect temperature with specialized neurons in the peripheral nervous system.
Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class …

A distinct subset of sensory neurons are thought to directly sense changes in thermal
energy through their termini in the skin. Very little is known about the molecules that mediate …

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate
in the skin. Three members of the transient receptor potential (TRP) family of channels are …

We possess an acute sense of temperature. Most of us seek shade on a hot summer day,
prefer a warm shower to a cold one, and enjoy red wines served at a temperature of 15–18C. …

Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops
through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel, is a …

Several members of the TRP (for transient receptor potential) family of ion channels act as
physiological temperature sensors in mammals 1 , 2 , 3 , 4 , 5 , 6 , but it is not known whether …

Fragile X syndrome is a common cause of mental retardation involving loss of expression of
the FMR1 gene. The role of FMR1 remains undetermined but the protein appears to be …

Nearly all cases of fragile X syndrome result from expansion of a CGG trinucleotide repeat
found in the 5′ untranslated portion of the FMR1 gene 1 . Methylation of the expanded …

Neuromedin U (NMU) is a highly conserved peptide reported to modulate energy homeostasis.
Pharmacological studies have shown that centrally administered NMU inhibits food …

Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic
diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine …