The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) …

Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …

In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra
pars compacta is associated with Lewy bodies arising from the accumulation of alpha-…

Background Microglia are the endogenous immune cells of the brain and act as sensors of
pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's …

Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds,
APOE4, PSEN1ΔE9, and APPswe, on functionality of human microglia-like cells (iMGLs). We …

Synaptic vesicles loaded with neurotransmitters fuse with the plasma membrane to release
their content into the extracellular space, thereby allowing neuronal communication. The …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in the …

The mechanisms controlling pain in newborns during delivery are poorly understood. We
explored the hypothesis that oxytocin, an essential hormone for labor and a powerful …

Formation, maturation, stabilization, and functional efficacy of the neuromuscular junction (NMJ)
are orchestrated by transsynaptic and autocrine signals embedded within the synaptic …

Recent studies suggested contribution of homocysteine (HCY) to neurodegenerative disorders
and migraine. However, HCY effect in the nociceptive system is essentially unknown. To …