The respiratory tract is constantly exposed to the external environment, and therefore, must
be equipped to respond to and eliminate pathogens. Viral clearance and resolution of …

OBJECTIVE: We sought to validate several clinical risk factors previously described for
preeclampsia in a large contemporary multicenter prospective cohort. METHODS: We enrolled …

The formation of a reactive intermediate was found to be responsible for CYP3A4
metabolism-dependent inhibition (MDI) observed with (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]-3-phenyl…

The long lasting antidepressant response seen following acute, iv ketamine administration
in patients with treatment-resistant depression (TRD) is thought to result from enhanced …

By taking advantage of certain features in piperidine 4, we developed a novel series of
cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Na v 1.7 …

(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an
orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 …

3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Na v 1.7
inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also …

Oxidized LDL (oxLDL) in the arterial wall and its incorporation into foam cells leads to
inflammation and nucleation of atherosclerotic plaque; this is opposed by HDL. OxLDL and HDL …

This report describes the synthesis, structure–activity relationships and activity of piperidine,
homopiperidine, and azocane derivatives combining NK 1 receptor (NK 1 R) antagonism …

Since zwitterionic benzenesulfonamide Na v 1.7 inhibitors suffer from poor membrane
permeability, we sought to eliminate this characteristic by replacing the basic moiety with non-…