Cardiovascular complications, characterized by endothelial dysfunction and accelerated
atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. …

The risk of cerebrovascular disease is four- to sixfold higher in patients with diabetes. Vascular
remodeling, characterized by extracellular matrix deposition and an increased media-to-…

Background While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion
injury in the brain, the relative contribution of neutrophils to the MMP activity and to …

Diabetes is associated with increased risk for complications following coronary bypass
grafting (CABG) surgery. Augmented superoxide \batchmode \documentclass[fleqn,10pt,…

Structure and function of the cerebrovasculature is critical for ischemic stroke outcome. We
showed that diabetes causes cerebrovascular remodeling by activation of the endothelin A (…

Diabetes increases the risk of stroke and contributes to poor clinical outcomes in this patient
population. Myogenic tone of the cerebral vasculature, including basilar arteries, plays a key …

Although past studies have demonstrated decreased renal matrix metalloproteinase (MMP)
activity in type 1 diabetes and in mesangial cells grown under high glucose conditions, renal …

OBJECTIVE—Vascular remodeling, characterized by extracellular matrix deposition and
increased media-to-lumen (M/l) ratio, contributes to the development of microvascular …

Vascular dysfunction, which presents either as an increased response to vasoconstrictors or
an impaired relaxation to dilator agents, results in worsened cardiovascular outcomes in …

Insulin resistance involves decreased phosphorylation of insulin receptor substrate (IRS)
proteins and (or) Akt. In the vasculature, modulated Akt phosphorylation may cause impaired …