Ethanol exerts its biological actions through multiple receptors, including ion channels. Ion
channels that are sensitive to pharmacologically relevant ethanol concentrations constitute a …

Large conductance, Ca 2+ - and voltage-gated K + (BK) channel proteins are ubiquitously
expressed in cell membranes and control a wide variety of biological processes. Membrane …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium- and voltage-gated potassium channels of large conductance …

The activity (Po) of large-conductance voltage/Ca 2+ -gated K + (BK) channels is blunted by
cholesterol levels within the range found in natural membranes. We probed BK channel–…

Ethanol alters BK (slo1) channel function leading to perturbation of physiology and behavior.
Site(s) and mechanism(s) of ethanol–BK channel interaction are unknown. We …

… Edited by Alex M. Dopico … Methods in Membrane Lipids, edited by Alex Dopico, 2007
399. Neuroprotection Methods and Protocols, edited by Tiziana Borsello, 2007 …

Objective— Hypercholesterolemia and alcohol drinking constitute independent risk factors
for cerebrovascular disease. Alcohol constricts cerebral arteries in several species, including …

Alcohol misuse has deleterious effects on personal health, family, societal units, and global
economies. Moreover, alcohol misuse usually leads to several diseases and conditions, …

Prenatal alcohol exposure often results in fetal alcohol syndrome and fetal alcohol spectrum
disorders. Mechanisms of fetal brain damage by alcohol remain unclear. We used baboons (…

In most tissues, the function of Ca 2+ - and voltage-gated K + (BK) channels is modified in
response to ethanol concentrations reached in human blood during alcohol intoxication. In …