Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity
…, MJ Pérez, JE Manautou, AD Mottino - Pharmacological …, 2016 - Elsevier
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication, …
be safe when administered within its therapeutic range, but in cases of acute intoxication, …
Expression and localization of multidrug resistant protein mrp2 in rat small intestine
AD Mottino, T Hoffman, L Jennes, M Vore - Journal of Pharmacology and …, 2000 - ASPET
The expression of multidrug resistance-associated protein isoform 2 (mrp2), the ATP-dependent
export pump that mediates the transport of glucuronic acid-, glutathione-, and sulfate-…
export pump that mediates the transport of glucuronic acid-, glutathione-, and sulfate-…
[PDF][PDF] Altered localization and activity of canalicular Mrp2 in estradiol‐17β‐D‐glucuronide–induced cholestasis
AD Mottino, J Cao, LM Veggi, F Crocenzi… - …, 2002 - Wiley Online Library
Estradiol‐17β‐D‐glucuronide (E 2 17G), an endogenous metabolite of estradiol, induces a
potent dose‐dependent and reversible inhibition of bile flow in the rat. We analyzed the effect …
potent dose‐dependent and reversible inhibition of bile flow in the rat. We analyzed the effect …
Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis
CL Basiglio, EJS Pozzi, AD Mottino… - Chemico-biological …, 2009 - Elsevier
Silymarin (SIL) is a natural extract with hepatoprotective properties composed mainly of
flavonolignans, with silibinin (SB) being its principal constituent. SB is thought to be the main …
flavonolignans, with silibinin (SB) being its principal constituent. SB is thought to be the main …
Estradiol-17β-D-glucuronide induces endocytic internalization of Bsep in rats
FA Crocenzi, AD Mottino, J Cao… - American Journal …, 2003 - journals.physiology.org
Endocytic internalization of the multidrug resistance-associated protein 2 (Mrp2) was previously
suggested to be involved in estradiol-17β-d-glucuronide (E 2 17G)-induced cholestasis. …
suggested to be involved in estradiol-17β-d-glucuronide (E 2 17G)-induced cholestasis. …
Complement activation and disease: protective effects of hyperbilirubinaemia
…, F Pelusa, AM Almara, J Kapitulnik, AD Mottino - Clinical …, 2010 - portlandpress.com
Complement, an important effector mechanism of the immune system, is an enzymatic cascade
of approx. 30 serum proteins leading to the amplification of a specific humoral response. …
of approx. 30 serum proteins leading to the amplification of a specific humoral response. …
[HTML][HTML] Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents
AD Mottino, VA Catania - World journal of gastroenterology: WJG, 2008 - ncbi.nlm.nih.gov
The canalicular membrane represents the excretory pole of hepatocytes. Bile is an important
route of elimination of potentially toxic endo-and xenobiotics (including drugs and toxins), …
route of elimination of potentially toxic endo-and xenobiotics (including drugs and toxins), …
Ca2+-dependent protein kinase C isoforms are critical to estradiol 17β-d-glucuronide–induced cholestasis in the rat
…, ML Ruiz, AE Zucchetti, MG Roma, AD Mottino… - Hepatology, 2008 - journals.lww.com
The endogenous estradiol metabolite estradiol 17β-d-glucuronide (E 2 17G) induces an
acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt …
acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt …
[PDF][PDF] Phosphoinositide 3‐kinase/protein kinase B signaling pathway is involved in estradiol 17β‐d‐glucuronide–induced cholestasis: Complementarity with classical …
…, JM Pellegrino, JE Ochoa, AD Mottino… - …, 2010 - Wiley Online Library
Materials and Methods Materials Cholyl lysyl fluorescein (CLF) was a generous gift from Dr.
Charles O. Mills (Birmingham, United Kingdom). E217G, collagenase type A (from …
Charles O. Mills (Birmingham, United Kingdom). E217G, collagenase type A (from …
[HTML][HTML] Dynamic localization of hepatocellular transporters in health and disease
MG Roma, FA Crocenzi, AD Mottino - World journal of …, 2008 - ncbi.nlm.nih.gov
Vesicle-based trafficking of hepatocellular transporters involves delivery of the newly-synthesized
carriers from the rough endoplasmic reticulum to either the plasma membrane domain …
carriers from the rough endoplasmic reticulum to either the plasma membrane domain …