Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein.
…, LI Eckler, CL Jellis, AT Profy… - Proceedings of the …, 1989 - National Acad Sciences
The principal neutralizing determinant of human immunodeficiency virus type 1 (HIV-1) is
located in the external envelope protein, gp120, and has previously been mapped to a 24-…
located in the external envelope protein, gp120, and has previously been mapped to a 24-…
Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant
…, JP Davide, K Weinhold, JA Waterbury, AT Profy… - Science, 1990 - science.org
The principal neutralizing determinant (PND) of human immunodeficiency virus HIV-1 is
part of a disulfide bridged loop in the third variable region of the external envelope protein, …
part of a disulfide bridged loop in the third variable region of the external envelope protein, …
Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1
K Javaherian, AJ Langlois, GJ LaRosa, AT Profy… - Science, 1990 - science.org
The principal neutralizing determinant (PND) of human immunodeficiency virus (HIV)-1 resides
within the V 3 loop of the envelope protein. Antibodies elicited by peptides of this region …
within the V 3 loop of the envelope protein. Antibodies elicited by peptides of this region …
Effect of praliciguat on peak rate of oxygen consumption in patients with heart failure with preserved ejection fraction: the CAPACITY HFpEF randomized clinical trial
…, JP Seferovic, P Wilson, RS Mittleman, AT Profy… - Jama, 2020 - jamanetwork.com
Importance Heart failure with preserved ejection fraction (HFpEF) is often characterized by
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat, an …
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat, an …
Major antigen-induced domain rearrangements in an antibody
RL Stanfield, M Takimoto-Kamimura, JM Rini, AT Profy… - Structure, 1993 - cell.com
Background: Recent structural results have shown that Analysis of other Fab structures
suggests that the exantibodies use an induced fit mechanism to recognize tent of the surface …
suggests that the exantibodies use an induced fit mechanism to recognize tent of the surface …
Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities
…, KJ Willis, MS Osburne, AT Profy… - Antimicrobial agents …, 1996 - Am Soc Microbiol
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar
affinity and block binding of gp120. Both have activity against human immunodeficiency …
affinity and block binding of gp120. Both have activity against human immunodeficiency …
PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity
Objective: Vaginal microbicides should protect against infection without disrupting the mucosal
environment or its mediators of host defense. The objective of this study was to examine …
environment or its mediators of host defense. The objective of this study was to examine …
Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.
…, EA Stura, PA Salinas, AT Profy… - Proceedings of the …, 1993 - National Acad Sciences
The crystal structure of the Fab fragment of a human immunodeficiency virus type 1 (HIV-1)
neutralizing monoclonal antibody Fab has been determined at 2.8 A resolution in complex …
neutralizing monoclonal antibody Fab has been determined at 2.8 A resolution in complex …
Crystal structure of the principal neutralization site of HIV-1
JB Ghiara, EA Stura, RL Stanfield, AT Profy, IA Wilson - Science, 1994 - science.org
The crystal structure of a complex between a 24-amino acid peptide from the third variable (V3)
loop of human immunodeficiency virus-type 1 (HIV-1) gp120 and the Fab fragment of a …
loop of human immunodeficiency virus-type 1 (HIV-1) gp120 and the Fab fragment of a …
Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action
…, MJ Keller, K Hogarty, DP Waller, AT Profy… - Antimicrobial agents …, 2005 - Am Soc Microbiol
Poly(styrene 4-sulfonate), cellulose sulfate, polymethylenehydroquinone, and PRO 2000 are
sulfated or sulfonated polymers (SPs) under development as topical microbicides. They are …
sulfated or sulfonated polymers (SPs) under development as topical microbicides. They are …