Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism …

Scarring of the kidney is a major public health concern, directly promoting loss of kidney
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring in …

Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism.
MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle …

We developed a systematic approach to map human genetic networks by combinatorial
CRISPR–Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs …

The hypoxia-inducible factor (HIF) pathway is essential for cell survival under low oxygen
and plays an important role in tumor cell homeostasis. We investigated the function of miR-210…

MYC oncogene family members are broadly implicated in human cancers, yet are considered
“undruggable” as they encode transcription factors. MYC also carries out essential …

It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search for …

The function of GATA transcription factors in diverse developmental contexts depends in
part on physical interaction with cofactors of the Friend of GATA (FOG) family. However, …

Transcription factors GATA-1 and GATA-2 are required for normal hematopoiesis. The loss
of either leads to embryonic lethality in knockout mice because of the failure of erythroid …

Objective Gastric cancer (GC) remains difficult to cure due to heterogeneity in a clinical
challenge and the molecular mechanisms underlying this disease are complex and not …