The development of monoamine oxidase (MAO) inhibitors has followed a winding path. At
the origin was the finding of EA Zeller that iproniazid, a hydrazine derivative designed to …

In recent years, evidence has been obtained that aromatic monoamines-for example,
catecholamines and 5-hydroxytryptamine (5HT)-might function as neurohumoral transmitters in the …

Modern treatment of mental depression started with the availability of monoamine oxidase (MAO)
inhibitors and tricyclic antidepressants. These drugs also contributed to the early …

1. A fluorometric method for the determination of serotonin (5-hydroxytryp-tamine) in brain is
described. The procedure involves the use of a spectrophoto-fluorometer which can activate …

(Fig. 2). Page 1 a pressure maximum to occur within the zone in which depletion has occurred.
Between the inflow face and the pressure maximum a hydraulic countercurrent moves …

N-(DL-seryl)-N′-(2,3,4-trihydroxybenzyl)-hydrazine (HCl) (Ro 4-4602) is a strong inhibitor
of decarboxylase of aromatic amino-acids in vivo and in vitro 1,2 . The drug counteracts the …

The finding of serotonin (5-hydroxy-tryptamine) in brain (1, 2) has aroused speculation that
it may have a-role in brain function (3), perhaps as a neuro-humoral agent (4). Studies from …

The biological effects of cyclosporin, namely immunosuppression and absence of cytotoxicity,
were discovered in the course of a general screening program in which many scientists at …

The administration of reserpine to rabbits in doses as low as 0.1 mgm. per kgm. releases
serotonin in brain. This observation supports the view that serotonin has a role in brain …

Platelets show similarities with 5-hydroxytryptaminergic neurons with respect to (1) uptake
kinetics of 5-hydroxytryptamine (5-HT) at the plasma membrane, (2) inhibitory effects of …