The area covered by boreal forests accounts for∼ 16% of the global and 22% of the Northern
Hemisphere landmass. Changes in the productivity and functioning of this circumpolar …

Dedicated the memory of Akademician Valery Vasilievich Lunin, a friend, colleague, teacher,
founder and leader of the research into application of supercritical fluids in chemistry. …

The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene
silencing as well as aging in yeast. Here, we show that mammalian Sir2α physically interacts …

The p53 tumour suppressor is a short-lived protein that is maintained at low levels in normal
cells by Mdm2-mediated ubiquitination and subsequent proteolysis 1 , 2 , 3 . Stabilization of …

Deregulation of intestinal immune responses seems to have a principal function in the
pathogenesis of inflammatory bowel disease 1 , 2 , 3 , 4 . The gut epithelium is critically involved …

Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections
during development, but their mechanistic basis remains poorly understood. Here we …

Alterations of TGF-β signaling have been described in colorectal cancer, although the molecular
consequences are largely unknown. By using transgenic mice overexpressing TGF-β or …

Purpose: Combination strategies leveraging chemotherapeutic agents and immunotherapy
have held the promise as a method to improve benefit for patients with cancer. However, …

Scopolamine produces rapid and significant symptom improvement in patients with depression,
and most notably in patients who do not respond to current antidepressant treatments. …

Granulomatous mastitis ( GM ) is a relatively uncommon inflammatory breast lesion with
multiple suggested etiologies. Although most GM cases show association with lactation and …