Su-8629 (2-amino-indane) has oral analgesic potency and a therapeutic index comparable
to morphine sulfate; it is unlike morphine in that it does not depress respiration and is not …

[2-(Octahydro-1-azocinyl)-ethyl]-guanidine sulfate (Su-5864) profoundly lowered the arterial
pressure of unanesthetized neurogenic and renal hypertensive dogs. It had a slight …

The synthesis of a series of tertiary iudai «unities and related compounds containing an N-2-pmpyiiyl
sub-stituent is described. Among this series are two (1 and 10, Table I) which are …

The cardiovascular and respiratory effects of Serpasil, a crystalline alkaloid obtained from
Rauwolfia serpentina Benth, have been studied in the dog. Following the intravenous injection …

1. On the basis of comparative minimally effective diuretic doses, hydrochlorothiazide was
eight times as active as chlorothiazide, and on the basis of doseresponse effects, it was 6.3 …

METHODS. The various substances studied were tested intravenously for ganglionic blocking
activity in forty cats anesthetized with Dial-Urethane. The intravenous dose of the agent …

Guanethidine (Su-5864) alters the response to a series of pressor phenylalkylamines such
that the amines can be placed in three categories: 1) augmented or not suppressed are the …

The blood pressure responses to a series of pressor amines of the phenylalkylamine type are
altered following reserpine administration such that amines possessing "See image in the …

RESULTS. Unanesthetized animals: A. Symptomatology. In all species tested the effect of
deserpidine was characterized by a state of tranquilization or inactivation, which could not be …

Hydrochlorothiazide may be determined in urine by extracting with ethyl acetate and either
reacting directly with chromotropic acid or hydrolyzing first with alkali followed by …