Physicochemical determinants for drug induced blockade of HERG potassium channels: effect of charge and charge shielding

AB Zolotoy, BP Plouvier, GB Beatch… - Current Medicinal …, 2003 - ingentaconnect.com
… (Merck Molecular force field) and ab initio (3-21*G basis) calculations. One should note that
molecular mechanics and ab initio calculations overestimate the energy of hydrogen bonds …

Ischaemia selectivity confers efficacy for suppression of ischaemia-induced arrhythmias in rats

TD Barrett, ES Hayes, SL Yong, AB Zolotoy… - European journal of …, 2000 - Elsevier
Eight novel and three reference antiarrhythmics were investigated in anaesthetised rats for
antiarrhythmic actions, as well as for effects on the electrocardiogram (ECG) under normal …

Molecular modeling for oxidative cross-linking of oleates adsorbed on surfaces of minerals

D Arad, M Kaftory, AB Zolotoy, NP Finkelstein… - Langmuir, 1993 - ACS Publications
Fatty acids, prominent among them oleic acid, are used to change the surface properties of
calcium-and magne-sium-containing minerals and other solid phases in in-dustrial practice, …

RSD1000: a novel antiarrhythmic agent with increased potency under acidic and high-potassium conditions

SL Yong, R Xu, JG McLarnon, AB Zolotoy… - … of Pharmacology and …, 1999 - ASPET
This study reports the use of a novel agent, RSD1000 [(±)-trans-[2-(4-morpholinyl)cyclohexyl]naphthalene-1-acetate
mono hydrochloride], to test the hypothesis that a drug with pK a …

Crystal and molecular structure of 5-ethyl-5, 10-dihydrido-10, 10-diphenylphenazasiline

AB Zolotoy, OA D'yachenko, LO Atovmyan… - Journal of …, 1980 - Elsevier
The structure of 5-ethyl-5,10-dihydro-10,10-diphenylphenazasiline has been determined
from three-dimensional X-ray data collected by counter methods. The compound in the …

1-Methyl-5, 6-diphenylpyrazine-2 (1H)-thione

AB Zolotoy, M Botoshansky, M Kaftory… - … Section C: Crystal …, 2002 - scripts.iucr.org
The title compound, C17H14N2S, crystallizes in a triclinic unit cell, with two crystallographically
independent molecules in the asymmetric unit. The two independent molecules pack in …

Molecular structure of 1-ammo-5-acetyl-4, 5-dimethyl-2, 3, 3-tricyanocyclopentene

SV Konovalikhin, AB Zolotoy, LO Atovmyan - Russian Chemical Bulletin, 1993 - Springer
The structure of 1-amino-5-acetyl-4,5-dimethyl-2,3,3-tricyanocyclopentene was determined
by X-ray analysis. The origin of the observed molecular conformation and lengthening of the …

1-Methyl-5, 6, 7, 8-tetrahydroquinoxalin-2 (1H)-one

AB Zolotoy, M Botoshansky, M Kaftory - … Crystallographica Section C …, 2002 - scripts.iucr.org
The title compound, C9H12N2O, crystallizes in a triclinic unit cell, with two crystallographically
independent molecules in the asymmetric unit. The two independent molecules adopt …

Ventricular fibrillation, an uncontrolled arrhythmia seeking new targets

…, B Plouvier, G Jung, RA Wall, A Zolotoy… - Drug development …, 2002 - Wiley Online Library
… These drugs should have no proarrhythmic actions in normal tissue; however, by preventing
the abbreviation of action potentials that limits calcium entry in ischemic cells, these drugs …

[CITATION][C] Abe, Y., see Tamura, K. 398 317 Ž.

…, TD Barrett, ES Hayes, SL Yong, AB Zolotoy… - European Journal of …, 2000