Comparative CD and Fourier transform ir (FTIR) spectroscopic data on N‐Boc protected
linear peptides with or without the (Pro‐Gly) β‐turn motif (eg, Boc‐Tyr‐Pro‐Gly‐Phe‐Leu‐OH …

The effect of clonidine on ethanol-induced gastric mucosal damage, gastric emptying and
gastric motility was compared. The clonidine-induced gastroprotective effect (0.03–0.09 μmol/…

Our recent study [1] on synthetic analogs of enkephalins (Tyr-Gly-Gly-Phe-X, X= Met and Leu
[2]) has revealed some structural requirements for a pentapeptide to exert antinociceptive …

This study evaluated the contribution of supraspinal opioid receptors to gastric mucosal
protection in the rat. Intracerebroventricular (icv) and intracisternal (ic) injections of selective δ- {[d…

Clonidine inhibited the development of gastric mucosal lesions induced by either acidified
ethanol or indomethacin. The ED 50 values were: 7.1 and 5.2 μg.kg –1 orally, respectively. …

HUGHES et al. have reported the isolation and structure of two pentapeptides from porcine
brain with opiate agonist activity in isolated systems. The structure of one of these peptides, …

Repeated administration of morphine resulted in significant reduction of its analgesic potency.
If 0.1 mg/kg α-MSH was coadministered, the tolerance development was attenuated, 1 mg/…

Increasing number of evidence suggest that gastric mucosal protection can be induced also
centrally. Several neuropeptides, such as TRH, amylin, adrenomedullin, enkephalin, β-…

Endomorphins-1 and -2 were substituted with all the β-MePhe stereoisomers in their Phe
residues to generate a conformationally constrained peptide set. This series of molecules was …

The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol)
function were compared to the parent amidated compounds in isolated organs (longitudinal …