Optical aggregometry, traditionally used to assess platelet function, is highly dependent on
sample preparation and technical procedure; as a result, data from various laboratories can …

BACKGROUND AND PURPOSE Cannabinoid CB 2 receptor activation by selective agonists
has been shown to produce analgesic effects in preclinical models of inflammatory and …

Background and purpose: Selective cannabinoid CB 2 receptor agonists have demonstrated
analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative …

The histamine H 4 receptor (H 4 R) is expressed primarily on cells involved in inflammation
and immune responses. To determine the potential role of H 4 R in pain transmission, the …

… , A-836339 also failed to displace [ 3 H]DAMGO at the μ-opioid receptor at concentrations
up to 10 μM (data not shown), whereas the μ-opioid receptor ligand naloxone exhibited a K i …

Background Injection of nerve growth factor ( NGF ) produces mechanical and thermal
hypersensitivity in rodents and humans. Treatment with sequestering antibodies demonstrates the …

This study was designed to evaluate the antithrombotic efficacy and bleeding propensity of a
selective, small-molecule inhibitor of tissue factor/factor VIIa (TF/VIIa) in comparison to small…

A key role has been established for platelet activation and thrombus formation in the
pathogenesis of acute coronary syndromes, and restenosis after percutaneous interventions. …

The histamine H 3 receptor is predominantly expressed in the central nervous system and
plays a role in diverse physiological mechanisms. In the present study, the effects of …

Background Intravenous therapy has been shown to be beneficial in the prevention of acute
platelet-associated thrombotic events. However, orally active agents would be …