… to examine the distribution of dynorphin and enkephalin (Basbaum et al1983a). One antibody
was … In press Glazer, EJ , Basbaum, AI 1983b. Serotonin axons synapse on enkephalin …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

The sensation of pain alerts us to real or impending injury and triggers appropriate protective
responses. Unfortunately, pain often outlives its usefulness as a warning system and …

The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory
neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid …

Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits burning pain by activating
specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (…

TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic.
TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) …

… Basbaum AI: <.onduction of the effects of noxious … Basbaum AI: Brainstcm control of
spinal pun transmission nrurons Annu Rev Physiol 40: 193-221. 1978 Fields HL, Basbaum Al. …

Tissue injury generates endogenous factors that heighten our sense of pain by increasing
the response of sensory nerve endings to noxious stimuli 1 , 2 . Bradykinin and nerve growth …

Sensory nerve fibres can detect changes in temperature over a remarkably wide range, a
process that has been proposed to involve direct activation of thermosensitive excitatory …

Over the past several years information has been gathered in three major areas related to
pain transmission and its modulation. The new information concerns first, the nature and …