A comprehensive listing of bioactivation pathways of organic functional groups

…, E Callegari, KR Henne, AE Mutlib… - Current drug …, 2005 - ingentaconnect.com
The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a
drug has been released can lead to a severe restriction in its use and even in its withdrawal. …

[PDF][PDF] Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

GM Bores, FP Huger, W Petko, AE Mutlib… - … of Pharmacology and …, 1996 - researchgate.net
Acetylcholinesterase(AChE) inhibitors from several chemical classes have been tested for
the symptomatic treatment of Alzheimer’s disease; however, the therapeutic success of these …

Application of stable isotope-labeled compounds in metabolism and in metabolism-mediated toxicity studies

AE Mutlib - Chemical research in toxicology, 2008 - ACS Publications
Stable isotope-labeled compounds have been synthesized and utilized by scientists from
various areas of biomedical research during the last several decades. Compounds labeled …

Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of …

AE Mutlib, H Chen, GA Nemeth, JA Markwalder… - Drug Metabolism and …, 1999 - ASPET
Efavirenz (Sustiva, Fig. 1 ) is a potent and specific inhibitor of HIV-1 reverse transcriptase
approved for the treatment of HIV infection. To examine the potential differences in the …

The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats

AE Mutlib, RJ Gerson, PC Meunier, PJ Haley… - Toxicology and applied …, 2000 - Elsevier
… Efavirenz is metabolized extensively in a species-specific manner including the formation
of a novel cysteinylglycine conjugate (Mutlib et al., 1999a,b). This conjugate results from the …

Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells

…, DA Jackson, P Kulanthaivel, AE Mutlib… - Chemical research in …, 2003 - ACS Publications
Capsaicin is a common dietary constituent and a popular homeopathic treatment for chronic
pain. Exposure to capsaicin has been shown to cause various dose-dependent acute …

Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen− Induced …

AE Mutlib, TC Goosen, JN Bauman… - Chemical research in …, 2006 - ACS Publications
The importance of uridine 5‘-diphosphate-glucuronosyltranferases (UGT) 2B15 and other
UGT enzymes (1A1, 1A6, and 1A9) in glucuronidating acetaminophen (APAP) is demonstrated…

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone

…, R Kubik, J Hanson, E Urda, AE Mutlib - Toxicological …, 2006 - academic.oup.com
Abstract Treatment with the antidepressant nefazodone has been associated with clinical
idiosyncratic hepatotoxicty. Using membranes expressing human bile salt export pump (BSEP)…

Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone.

AE Mutlib, JT Strupczewski, SM Chesson - Drug Metabolism and …, 1995 - ASPET
Iloperidone, 1(-)[4(-)[3(-)[4-(6-fluro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone,
is currently undergoing clinical trials as a potential antipsychotic agent. …

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4 …

…, JR Soglia, J Atherton, L Yu, AE Mutlib… - Chemical research in …, 2007 - ACS Publications
The current study examined the bioactivation potential of a nonpeptidyl thrombopoietin
receptor agonist, 1-(3-chloro-5-((4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)…