User profiles for A Bobik

Alexander Bobik

Monash University
Verified email at monash.edu
Cited by 2599

Transforming growth factor-βs and vascular disorders

A Bobik - Arteriosclerosis, thrombosis, and vascular biology, 2006 - Am Heart Assoc
Transforming growth factor-β (TGF-β) superfamily members, TGF-β and bone morphogenetic
proteins (BMPs), are potent regulatory cytokines with diverse functions on vascular cells. …

Understanding the role of transforming growth factor-β1 in intimal thickening after vascular injury

R Khan, A Agrotis, A Bobik - Cardiovascular research, 2007 - academic.oup.com
Intimal thickening is the most important cause of in-stent restenosis. The pathology of intimal
thickening is attributable to a local inflammatory response after vascular injury which results …

Atherosclerotic plaque rupture: identifying the straw that breaks the camel's back

YC Chen, AL Huang, TS Kyaw, A Bobik… - … , and vascular biology, 2016 - Am Heart Assoc
e64 Arterioscler Thromb Vasc Biol August 2016 plaques. Magnetic resonance imaging (MRI)
and positron emission tomography, and in particular the combination of both, providing soft-…

Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines

…, O Ilyinskaya, E Tararak, A Bobik - … , and vascular biology, 2004 - Am Heart Assoc
Objective— Atherosclerosis is a chronic inflammatory response of the arterial wall to injury.
High-mobility group box 1 (HMGB1) is a DNA-binding protein, which on release from cells …

Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis

…, R Dunn, A Agrotis, P Tipping, A Bobik… - The Journal of …, 2010 - journals.aai.org
Atherosclerosis is a chronic inflammatory arterial disease characterized by focal accumulation
of lipid and inflammatory cells. It is the number one cause of deaths in the Western world …

Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque

JA Shaw, A Bobik, A Murphy, P Kanellakis… - Circulation …, 2008 - Am Heart Assoc
Studies have shown a reduction in plaque volume and change in plaque ultrasound
characteristics after 4 infusions of reconstituted high-density lipoprotein (rHDL). Whether rHDL …

B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions

…, P Kanellakis, A Agrotis, P Tipping, A Bobik… - Circulation …, 2011 - Am Heart Assoc
Rationale: Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced
atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized …

[PDF][PDF] Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

…, L Peijs, C Yang, S Risis, CR Bruce, XJ Du, A Bobik… - Cell metabolism, 2015 - cell.com
Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism. The pro-inflammatory
effects of IL-6 are mediated via IL-6 "trans-signaling," a process where the soluble …

Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques

…, I Ahrens, J Chin-Dusting, A Bobik… - Circulation …, 2009 - Am Heart Assoc
C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentamer (pentameric
CRP) in plasma. The in vivo existence of monomeric (m)CRP has been postulated, …

Cytotoxic and Proinflammatory CD8+ T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice

…, H Hosseini, A Cao, P Li, P Tipping, A Bobik… - Circulation, 2013 - Am Heart Assoc
Background— Heart attacks and strokes, leading causes of deaths globally, arise from
thrombotic occlusion of ruptured vulnerable atherosclerotic plaques characterized by abundant …