User profiles for A Bobik
Alexander BobikMonash University Verified email at monash.edu Cited by 2599 |
Transforming growth factor-βs and vascular disorders
A Bobik - Arteriosclerosis, thrombosis, and vascular biology, 2006 - Am Heart Assoc
Transforming growth factor-β (TGF-β) superfamily members, TGF-β and bone morphogenetic
proteins (BMPs), are potent regulatory cytokines with diverse functions on vascular cells. …
proteins (BMPs), are potent regulatory cytokines with diverse functions on vascular cells. …
Understanding the role of transforming growth factor-β1 in intimal thickening after vascular injury
R Khan, A Agrotis, A Bobik - Cardiovascular research, 2007 - academic.oup.com
Intimal thickening is the most important cause of in-stent restenosis. The pathology of intimal
thickening is attributable to a local inflammatory response after vascular injury which results …
thickening is attributable to a local inflammatory response after vascular injury which results …
Atherosclerotic plaque rupture: identifying the straw that breaks the camel's back
e64 Arterioscler Thromb Vasc Biol August 2016 plaques. Magnetic resonance imaging (MRI)
and positron emission tomography, and in particular the combination of both, providing soft-…
and positron emission tomography, and in particular the combination of both, providing soft-…
Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines
…, O Ilyinskaya, E Tararak, A Bobik - … , and vascular biology, 2004 - Am Heart Assoc
Objective— Atherosclerosis is a chronic inflammatory response of the arterial wall to injury.
High-mobility group box 1 (HMGB1) is a DNA-binding protein, which on release from cells …
High-mobility group box 1 (HMGB1) is a DNA-binding protein, which on release from cells …
Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis
…, R Dunn, A Agrotis, P Tipping, A Bobik… - The Journal of …, 2010 - journals.aai.org
Atherosclerosis is a chronic inflammatory arterial disease characterized by focal accumulation
of lipid and inflammatory cells. It is the number one cause of deaths in the Western world …
of lipid and inflammatory cells. It is the number one cause of deaths in the Western world …
Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque
JA Shaw, A Bobik, A Murphy, P Kanellakis… - Circulation …, 2008 - Am Heart Assoc
Studies have shown a reduction in plaque volume and change in plaque ultrasound
characteristics after 4 infusions of reconstituted high-density lipoprotein (rHDL). Whether rHDL …
characteristics after 4 infusions of reconstituted high-density lipoprotein (rHDL). Whether rHDL …
B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions
…, P Kanellakis, A Agrotis, P Tipping, A Bobik… - Circulation …, 2011 - Am Heart Assoc
Rationale: Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced
atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized …
atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized …
[PDF][PDF] Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
…, L Peijs, C Yang, S Risis, CR Bruce, XJ Du, A Bobik… - Cell metabolism, 2015 - cell.com
Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism. The pro-inflammatory
effects of IL-6 are mediated via IL-6 "trans-signaling," a process where the soluble …
effects of IL-6 are mediated via IL-6 "trans-signaling," a process where the soluble …
Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques
…, I Ahrens, J Chin-Dusting, A Bobik… - Circulation …, 2009 - Am Heart Assoc
C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentamer (pentameric
CRP) in plasma. The in vivo existence of monomeric (m)CRP has been postulated, …
CRP) in plasma. The in vivo existence of monomeric (m)CRP has been postulated, …
Cytotoxic and Proinflammatory CD8+ T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice
…, H Hosseini, A Cao, P Li, P Tipping, A Bobik… - Circulation, 2013 - Am Heart Assoc
Background— Heart attacks and strokes, leading causes of deaths globally, arise from
thrombotic occlusion of ruptured vulnerable atherosclerotic plaques characterized by abundant …
thrombotic occlusion of ruptured vulnerable atherosclerotic plaques characterized by abundant …