[HTML][HTML] Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes

G Remuzzi, A Benigni, A Remuzzi - The Journal of clinical …, 2006 - Am Soc Clin Investig
The incidence of chronic kidney diseases is increasing worldwide, and these conditions are
emerging as a major public health problem. While genetic factors contribute to susceptibility …

[HTML][HTML] Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

L Perico, A Benigni, F Casiraghi, LFP Ng… - Nature Reviews …, 2021 - nature.com
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …

[HTML][HTML] Understanding the nature of renal disease progression

G Remuzzi, P Ruggenenti, A Benigni - Kidney international, 1997 - Elsevier
Among the several theories on the pathophysiology of progressive nephropathies [1—41,
the most convincing one [1, 2] suggests that the initial reduction in nephron number …

Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure

…, D Rottoli, S Angioletti, A Benigni… - Journal of the …, 2004 - journals.lww.com
ABSTRACT. Injury to a target organ can be sensed by bone marrow stem cells that migrate
to the site of damage, undergo differentiation, and promote structural and functional repair. …

Angiotensin II revisited: new roles in inflammation, immunology and aging

A Benigni, P Cassis, G Remuzzi - EMBO molecular medicine, 2010 - embopress.org
That the renin–angiotensin system (RAS) is involved in regulation of blood pressure,
vasoconstriction, sodium intake and potassium excretion is well established. Studies in the last few …

[HTML][HTML] Disruption of the Ang II type 1 receptor promotes longevity in mice

A Benigni, D Corna, C Zoja, A Sonzogni… - The Journal of …, 2009 - Am Soc Clin Investig
The renin-angiotensin system plays a role in the etiology of hypertension and the pathophysiology
of cardiac and renal diseases in humans. Ang II is the central product of this system …

Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice

…, D Corna, M Abbate, C Rota, D Rottoli, A Benigni… - Stem …, 2008 - academic.oup.com
Transplantation of bone marrow mesenchymal stem cells (BM-MSC) or stromal cells from
rodents has been identified as a strategy for renal repair in experimental models of acute …

Should COVID-19 concern nephrologists? Why and to what extent? The emerging impasse of angiotensin blockade

L Perico, A Benigni, G Remuzzi - Nephron, 2020 - karger.com
Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney
diseases, including acute kidney injury, and examine the potential effects of ARBs on the …

Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for ppregnancy-induced hypertension

A Benigni, G Gregorini, T Frusca… - … England Journal of …, 1989 - Mass Medical Soc
There is evidence that aspirin in low doses favorably influences the course of pppregnancy-induced
hypertension, but the mechanism, although assumed to involve suppression of the …

Recommendations for biomarker identification and qualification in clinical proteomics

…, T Attwood, M Baumann, A Benigni… - Science translational …, 2010 - science.org
Clinical proteomics has yielded some early positive results—the identification of potential
disease biomarkers—indicating the promise for this analytical approach to improve the current …