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Page 1
Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator.
Eur J Pharmacol. 2011 Jun 1;659(2-3):146-54. doi: 10.1016/j.ejphar.2011.02.003. Epub 2011 Feb 16.
Eur J Pharmacol. 2011.
PMID: 21335002
The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats.
Lelas S, Zeller KL, Ward KA, McElroy JF.
Lelas S, et al. Among authors: zeller kl.
Psychopharmacology (Berl). 2003 Apr;166(4):408-15. doi: 10.1007/s00213-002-1331-8. Epub 2003 Feb 18.
Psychopharmacology (Berl). 2003.
PMID: 12590355
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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats.
Lelas S, Wong H, Li YW, Heman KL, Ward KA, Zeller KL, Sieracki KK, Polino JL, Godonis HE, Ren SX, Yan XX, Arneric SP, Robertson DW, Hartig PR, Grossman S, Trainor GL, Taub RA, Zaczek R, Gilligan PJ, McElroy JF.
Lelas S, et al. Among authors: zeller kl.
J Pharmacol Exp Ther. 2004 Apr;309(1):293-302. doi: 10.1124/jpet.103.058784. Epub 2004 Jan 23.
J Pharmacol Exp Ther. 2004.
PMID: 14742750
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The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats.
McElroy JF, Ward KA, Zeller KL, Jones KW, Gilligan PJ, He L, Lelas S.
McElroy JF, et al. Among authors: zeller kl.
Psychopharmacology (Berl). 2002 Dec;165(1):86-92. doi: 10.1007/s00213-002-1239-3. Epub 2002 Oct 12.
Psychopharmacology (Berl). 2002.
PMID: 12474122
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