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Page 1
Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.
Kamble SH, Obeng S, León F, Restrepo LF, King TI, Berthold EC, Kanumuri SRR, Gamez-Jimenez LR, Pallares VLC, Patel A, Ho NP, Hampson A, McCurdy CR, McMahon LR, Wilkerson JL, Sharma A, Hiranita T. Kamble SH, et al. Among authors: restrepo lf. J Pharmacol Exp Ther. 2023 Jun;385(3):180-192. doi: 10.1124/jpet.122.001525. Epub 2023 Apr 5. J Pharmacol Exp Ther. 2023. PMID: 37019472 Free PMC article.
Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors.
León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR. León F, et al. Among authors: restrepo lf. J Med Chem. 2021 Sep 23;64(18):13510-13523. doi: 10.1021/acs.jmedchem.1c00726. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34467758 Free PMC article.
The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study.
Berthold EC, Kamble SH, Raju KS, Kuntz MA, Senetra AS, Mottinelli M, León F, Restrepo LF, Patel A, Ho NP, Hiranita T, Sharma A, McMahon LR, McCurdy CR. Berthold EC, et al. Among authors: restrepo lf. Drug Metab Dispos. 2022 Feb;50(2):158-167. doi: 10.1124/dmd.121.000640. Epub 2021 Nov 10. Drug Metab Dispos. 2022. PMID: 34759012 Free PMC article.
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats.
Crowley ML, Restrepo LF, Gamez-Jimenez LR, Patel A, Braun T, Pallares VLC, Ho NP, Reeves ME, McCurdy CR, McMahon LR, Hiranita T. Crowley ML, et al. Among authors: restrepo lf. J Pharmacol Toxicol Methods. 2021 Sep-Oct;111:107101. doi: 10.1016/j.vascn.2021.107101. Epub 2021 Jul 7. J Pharmacol Toxicol Methods. 2021. PMID: 34242797 Free PMC article.
Interactive Effects of µ-Opioid and Adrenergic-α 2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine.
Obeng S, Leon F, Patel A, Zuarth Gonzalez JD, Chaves Da Silva L, Restrepo LF, Gamez-Jimenez LR, Ho NP, Guerrero Calvache MP, Pallares VLC, Helmes JA, Shiomitsu SK, Soto PL, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T. Obeng S, et al. Among authors: restrepo lf. J Pharmacol Exp Ther. 2022 Dec;383(3):182-198. doi: 10.1124/jpet.122.001192. Epub 2022 Sep 24. J Pharmacol Exp Ther. 2022. PMID: 36153006 Free PMC article.
Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors.
Chear NJ, León F, Sharma A, Kanumuri SRR, Zwolinski G, Abboud KA, Singh D, Restrepo LF, Patel A, Hiranita T, Ramanathan S, Hampson AJ, McMahon LR, McCurdy CR. Chear NJ, et al. Among authors: restrepo lf. J Nat Prod. 2021 Apr 23;84(4):1034-1043. doi: 10.1021/acs.jnatprod.0c01055. Epub 2021 Feb 26. J Nat Prod. 2021. PMID: 33635670 Free PMC article.
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, León F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Obeng S, et al. Among authors: restrepo lf. J Med Chem. 2020 Jan 9;63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. Epub 2019 Dec 27. J Med Chem. 2020. PMID: 31834797 Free PMC article.
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
Obeng S, Wilkerson JL, León F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, Patel A, Pennington AE, Taylor VA, Ho NP, Braun T, Fortner JD, Crowley ML, Williamson MR, Pallares VLC, Mottinelli M, Lopera-Londoño C, McCurdy CR, McMahon LR, Hiranita T. Obeng S, et al. Among authors: restrepo lf. J Pharmacol Exp Ther. 2021 Mar;376(3):410-427. doi: 10.1124/jpet.120.000189. Epub 2020 Dec 31. J Pharmacol Exp Ther. 2021. PMID: 33384303 Free PMC article.
14 results