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S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors.
Millan MJ, Mannoury la Cour C, Novi F, Maggio R, Audinot V, Newman-Tancredi A, Cussac D, Pasteau V, Boutin JA, Dubuffet T, Lavielle G. Millan MJ, et al. Among authors: pasteau v. J Pharmacol Exp Ther. 2008 Feb;324(2):587-99. doi: 10.1124/jpet.107.126706. Epub 2007 Nov 16. J Pharmacol Exp Ther. 2008. PMID: 18024789
The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways.
Millan MJ, Gobert A, Lejeune F, Dekeyne A, Newman-Tancredi A, Pasteau V, Rivet JM, Cussac D. Millan MJ, et al. Among authors: pasteau v. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64. doi: 10.1124/jpet.103.051797. Epub 2003 May 15. J Pharmacol Exp Ther. 2003. PMID: 12750432