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1979 2
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6 beta-Bromopenicillanic acid inactivates beta-lactamase I.
Knott-Hunziker V, Orlek BS, Sammes PG, Waley SG. Knott-Hunziker V, et al. Among authors: orlek bs. Biochem J. 1979 Jan 1;177(1):365-7. doi: 10.1042/bj1770365. Biochem J. 1979. PMID: 218563 Free PMC article.
The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.
Bailey JM, Scott JS, Basilla JB, Bolton VJ, Boyfield I, Evans DG, Fleury E, Heightman TD, Jarvie EM, Lawless K, Matthews KL, McKay F, Mok H, Muir A, Orlek BS, Sanger GJ, Stemp G, Stevens AJ, Thompson M, Ward J, Vaidya K, Westaway SM. Bailey JM, et al. Among authors: orlek bs. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6452-8. doi: 10.1016/j.bmcl.2009.09.027. Epub 2009 Sep 12. Bioorg Med Chem Lett. 2009. PMID: 19804969
Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.
Bromidge SM, Brown F, Cassidy F, Clark MS, Dabbs S, Hadley MS, Hawkins J, Loudon JM, Naylor CB, Orlek BS, Riley GJ. Bromidge SM, et al. Among authors: orlek bs. J Med Chem. 1997 Dec 19;40(26):4265-80. doi: 10.1021/jm9702903. J Med Chem. 1997. PMID: 9435896
14 results