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Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines and isosteric analogues of imidazoline.
Le Bihan G, Rondu F, Pelé-Tounian A, Wang X, Lidy S, Touboul E, Lamouri A, Dive G, Huet J, Pfeiffer B, Renard P, Guardiola-Lemaître B, Manéchez D, Pénicaud L, Ktorza A, Godfroid JJ. Le Bihan G, et al. Among authors: manechez d. J Med Chem. 1999 May 6;42(9):1587-603. doi: 10.1021/jm981099b. J Med Chem. 1999. PMID: 10229628 Free article.
Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines.
Rondu F, Le Bihan G, Wang X, Lamouri A, Touboul E, Dive G, Bellahsene T, Pfeiffer B, Renard P, Guardiola-Lemaitre B, Manechez D, Penicaud L, Ktorza A, Godfroid JJ. Rondu F, et al. Among authors: manechez d. J Med Chem. 1997 Nov 7;40(23):3793-803. doi: 10.1021/jm9608624. J Med Chem. 1997. PMID: 9371245 Free article.
Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.
Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, Guardiola-Lemaître B, Godfroid JJ, Pénicaud L, Morgan NG, Ktorza A. Pelé-Tounian A, et al. Among authors: manechez d. Eur J Pharmacol. 1999 Jul 14;377(1):81-7. doi: 10.1016/s0014-2999(99)00395-7. Eur J Pharmacol. 1999. PMID: 10448930