Protective effect of propylthiouracil independent of its hypothyroid effect on acetaminophen toxicity in the rat

J Pharmacol Exp Ther. 1982 Feb;220(2):427-32.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaminophen / antagonists & inhibitors*
  • Acetaminophen / toxicity
  • Animals
  • Glutathione / metabolism
  • Hyperthyroidism / metabolism
  • Hypothyroidism / chemically induced
  • Hypothyroidism / metabolism*
  • Liver / drug effects
  • Liver / metabolism
  • Liver Glycogen / metabolism
  • Male
  • Propylthiouracil / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Transaminases / metabolism
  • Triiodothyronine / pharmacology

Substances

  • Liver Glycogen
  • Triiodothyronine
  • Acetaminophen
  • Propylthiouracil
  • Transaminases
  • Glutathione