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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 1
1997 2
1998 5
2000 1
2003 4
2004 2
2005 4
2006 3
2007 3
2008 3
2009 2
2010 2
2011 2
2024 0

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32 results

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Page 1
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Isaacs RC, Newton CL, Cutrona KJ, Mercer SP, Payne LS, Stauffer KJ, Williams PD, Cook JJ, Krueger JA, Lewis SD, Lucas BJ, Lyle EA, Lynch JJ, McMasters DR, Naylor-Olsen AM, Michener MT, Wallace AA. Isaacs RC, et al. Among authors: lyle ea. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1536-40. doi: 10.1016/j.bmcl.2010.12.105. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21295467
Alterations in peripheral blood lymphocyte cytokine expression in obesity.
O'Rourke RW, Kay T, Lyle EA, Traxler SA, Deveney CW, Jobe BA, Roberts CT Jr, Marks D, Rosenbaum JT. O'Rourke RW, et al. Among authors: lyle ea. Clin Exp Immunol. 2006 Oct;146(1):39-46. doi: 10.1111/j.1365-2249.2006.03186.x. Clin Exp Immunol. 2006. PMID: 16968396 Free PMC article.
Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.
Coburn CA, Rush DM, Williams PD, Homnick C, Lyle EA, Lewis SD, Lucas BJ Jr, Di Muzio-Mower JM, Juliano M, Krueger JA, Vastag K, Chen IW, Vacca JP. Coburn CA, et al. Among authors: lyle ea. Bioorg Med Chem Lett. 2000 May 15;10(10):1069-72. doi: 10.1016/s0960-894x(00)00170-0. Bioorg Med Chem Lett. 2000. PMID: 10843219
3-amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors.
Sanderson PE, Cutrona KJ, Savage KL, Naylor-Olsen AM, Bickel DJ, Bohn DL, Clayton FC, Krueger JA, Lewis SD, Lucas BJ, Lyle EA, Wallace AA, Welsh DC, Yan Y. Sanderson PE, et al. Among authors: lyle ea. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1441-4. doi: 10.1016/s0960-894x(03)00154-9. Bioorg Med Chem Lett. 2003. PMID: 12668008
9-hydroxyazafluorenes and their use in thrombin inhibitors.
Stauffer KJ, Williams PD, Selnick HG, Nantermet PG, Newton CL, Homnick CF, Zrada MM, Lewis SD, Lucas BJ, Krueger JA, Pietrak BL, Lyle EA, Singh R, Miller-Stein C, White RB, Wong B, Wallace AA, Sitko GR, Cook JJ, Holahan MA, Stranieri-Michener M, Leonard YM, Lynch JJ Jr, McMasters DR, Yan Y. Stauffer KJ, et al. Among authors: lyle ea. J Med Chem. 2005 Apr 7;48(7):2282-93. doi: 10.1021/jm049423s. J Med Chem. 2005. PMID: 15801822
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
Liverton NJ, Bednar RA, Bednar B, Butcher JW, Claiborne CF, Claremon DA, Cunningham M, DiLella AG, Gaul SL, Libby BE, Lyle EA, Lynch JJ, McCauley JA, Mosser SD, Nguyen KT, Stump GL, Sun H, Wang H, Yergey J, Koblan KS. Liverton NJ, et al. Among authors: lyle ea. J Med Chem. 2007 Feb 22;50(4):807-19. doi: 10.1021/jm060983w. Epub 2007 Jan 24. J Med Chem. 2007. PMID: 17249648
32 results