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Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins.
Yamaguchi-Sasaki T, Tokura S, Ogata Y, Kawaguchi T, Sugaya Y, Takahashi R, Iwakiri K, Abe-Kumasaka T, Yoshida I, Arikawa K, Sugiyama H, Kanuma K. Yamaguchi-Sasaki T, et al. Among authors: kanuma k. ACS Med Chem Lett. 2020 Apr 10;11(6):1145-1151. doi: 10.1021/acsmedchemlett.0c00008. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32550994 Free PMC article.
Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors.
Yamaguchi-Sasaki T, Tamura Y, Ogata Y, Kawaguchi T, Kurosaka J, Sugaya Y, Iwakiri K, Busujima T, Takahashi R, Ueda-Yonemoto N, Tanigawa E, Abe-Kumasaka T, Sugiyama H, Kanuma K. Yamaguchi-Sasaki T, et al. Among authors: kanuma k. Chem Pharm Bull (Tokyo). 2020;68(4):345-362. doi: 10.1248/cpb.c19-00895. Chem Pharm Bull (Tokyo). 2020. PMID: 32238652 Free article.
Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties.
Yamaguchi-Sasaki T, Kawaguchi T, Okada A, Tokura S, Tanaka-Yamamoto N, Takeuchi T, Ogata Y, Takahashi R, Kurimoto-Tsuruta R, Tamaoki T, Sugaya Y, Abe-Kumasaka T, Arikawa K, Yoshida I, Sugiyama H, Kanuma K, Yoshinaga M. Yamaguchi-Sasaki T, et al. Among authors: kanuma k. Bioorg Med Chem. 2020 Dec 15;28(24):115818. doi: 10.1016/j.bmc.2020.115818. Epub 2020 Oct 31. Bioorg Med Chem. 2020. PMID: 33190073
Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.
Semple G, Tran TA, Kramer B, Hsu D, Han S, Choi J, Vallar P, Casper MD, Zou N, Hauser EK, Thomsen W, Whelan K, Sengupta D, Morgan M, Sekiguchi Y, Kanuma K, Chaki S, Grottick AJ. Semple G, et al. Among authors: kanuma k. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6166-71. doi: 10.1016/j.bmcl.2009.09.003. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19773162
13 results