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Year Number of Results
2012 2
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2019 1
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13 results

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Glucocorticoid receptor modulators decrease alcohol self-administration in male rats.
McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. McGinn MA, et al. Among authors: hunt hj. Neuropharmacology. 2021 May 1;188:108510. doi: 10.1016/j.neuropharm.2021.108510. Epub 2021 Feb 26. Neuropharmacology. 2021. PMID: 33647278 Free PMC article.
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals.
Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Vendruscolo LF, et al. Among authors: hunt hj. J Clin Invest. 2015 Aug 3;125(8):3193-7. doi: 10.1172/JCI79828. Epub 2015 Jun 29. J Clin Invest. 2015. PMID: 26121746 Free PMC article. Clinical Trial.
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E. Hunt HJ, et al. J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28368581
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Webster SP, et al. Among authors: hunt hj. Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. Br J Pharmacol. 2017. PMID: 28012176 Free PMC article. Clinical Trial.
13 results