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Page 1
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA. Garcia-Calvo M, et al. Among authors: crona jh. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. doi: 10.1073/pnas.0500269102. Epub 2005 May 31. Proc Natl Acad Sci U S A. 2005. PMID: 15928087 Free PMC article.
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
Cosford ND, Bleicher L, Herbaut A, McCallum JS, Vernier JM, Dawson H, Whitten JP, Adams P, Chavez-Noriega L, Correa LD, Crona JH, Mahaffy LS, Menzaghi F, Rao TS, Reid R, Sacaan AI, Santori E, Stauderman KA, Whelan K, Lloyd GK, McDonald IA. Cosford ND, et al. Among authors: crona jh. J Med Chem. 1996 Aug 16;39(17):3235-7. doi: 10.1021/jm960328w. J Med Chem. 1996. PMID: 8765504 No abstract available.
Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells.
Stauderman KA, Mahaffy LS, Akong M, Veliçelebi G, Chavez-Noriega LE, Crona JH, Johnson EC, Elliott KJ, Gillespie A, Reid RT, Adams P, Harpold MM, Corey-Naeve J. Stauderman KA, et al. Among authors: crona jh. J Pharmacol Exp Ther. 1998 Feb;284(2):777-89. J Pharmacol Exp Ther. 1998. PMID: 9454827
The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.
Altmann SW, Davis HR Jr, Yao X, Laverty M, Compton DS, Zhu LJ, Crona JH, Caplen MA, Hoos LM, Tetzloff G, Priestley T, Burnett DA, Strader CD, Graziano MP. Altmann SW, et al. Among authors: crona jh. Biochim Biophys Acta. 2002 Jan 30;1580(1):77-93. doi: 10.1016/s1388-1981(01)00190-1. Biochim Biophys Acta. 2002. PMID: 11923102
Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.
Gu Z, Graci JD, Lahser FC, Breslin JJ, Jung SP, Crona JH, McMonagle P, Xia E, Liu S, Karp G, Zhu J, Huang S, Nomeir A, Weetall M, Almstead NG, Peltz SW, Tong X, Ralston R, Colacino JM. Gu Z, et al. Among authors: crona jh. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. doi: 10.1128/AAC.00527-13. Epub 2013 Apr 29. Antimicrob Agents Chemother. 2013. PMID: 23629699 Free PMC article.
Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.
Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ, Johnson EC. Chavez-Noriega LE, et al. Among authors: crona jh. J Pharmacol Exp Ther. 1997 Jan;280(1):346-56. J Pharmacol Exp Ther. 1997. PMID: 8996215
Characterization of the recombinant human neuronal nicotinic acetylcholine receptors alpha3beta2 and alpha4beta2 stably expressed in HEK293 cells.
Chavez-Noriega LE, Gillespie A, Stauderman KA, Crona JH, Claeps BO, Elliott KJ, Reid RT, Rao TS, Velicelebi G, Harpold MM, Johnson EC, Corey-Naeve J. Chavez-Noriega LE, et al. Among authors: crona jh. Neuropharmacology. 2000 Oct;39(13):2543-60. doi: 10.1016/s0028-3908(00)00134-9. Neuropharmacology. 2000. PMID: 11044726