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Linaclotide pharmacodynamics.
Busby RW, Zhang G. Busby RW, et al. P T. 2013 Jul;38(7):397. P T. 2013. PMID: 24049426 Free PMC article. No abstract available.
Metopimazine is primarily metabolized by a liver amidase in humans.
Busby RW, Cai X, Yang S, Ramos L, Venkatarangan L, Shen H, Wax S, Sadeque AJM, De Colle C. Busby RW, et al. Pharmacol Res Perspect. 2022 Feb;10(1):e00903. doi: 10.1002/prp2.903. Pharmacol Res Perspect. 2022. PMID: 34918875 Free PMC article. Clinical Trial.
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation.
Busby RW, Kessler MM, Bartolini WP, Bryant AP, Hannig G, Higgins CS, Solinga RM, Tobin JV, Wakefield JD, Kurtz CB, Currie MG. Busby RW, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):196-206. doi: 10.1124/jpet.112.199430. Epub 2012 Oct 22. J Pharmacol Exp Ther. 2013. PMID: 23090647
14 results