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Page 1
Convergent syntheses of 3,6-dihydroxydec-4-enolides.
Killen JC, Axford LC, Newberry SE, Simpson TJ, Willis CL. Killen JC, et al. Among authors: axford lc. Org Lett. 2012 Aug 17;14(16):4194-7. doi: 10.1021/ol3018566. Epub 2012 Jul 31. Org Lett. 2012. PMID: 22849633
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
Marro ML, Patterson AW, Lee L, Deng L, Reynolds A, Ren X, Axford L, Patnaik A, Hollis-Symynkywicz M, Casson N, Custeau D, Ames L, Loi S, Zhang L, Honda T, Blank J, Harrison TJ, Papillon JPN, Hamann LG, Marcinkeviciene J, Regard JB. Marro ML, et al. Among authors: axford l. J Pharmacol Exp Ther. 2018 Oct;367(1):147-154. doi: 10.1124/jpet.118.248435. Epub 2018 Aug 3. J Pharmacol Exp Ther. 2018. PMID: 30076263
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Patnaik A, Axford L, Deng L, Cohick E, Ren X, Loi S, Kecman S, Hollis-Symynkywicz M, Harrison TJ, Papillon JPN, Dales N, Hamann LG, Lee L, Regard JB, Marcinkeviciene J, Marro ML, Patterson AW. Patnaik A, et al. Among authors: axford l. Bioorg Med Chem. 2020 Jun 15;28(12):115548. doi: 10.1016/j.bmc.2020.115548. Epub 2020 May 12. Bioorg Med Chem. 2020. PMID: 32503688
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Regard JB, Harrison TJ, Axford J, Axford L, Lee L, Ren X, Deng L, Reynolds A, Mao J, Liu Q, Patnaik A, Cohick E, Hollis-Symynkywicz M, Loi S, Riek S, McKeever U, Dunstan D, Sung M, Ware NF, Brown AP, Hamann LG, Marcinkeviciene J, Patterson AW, Marro ML. Regard JB, et al. Among authors: axford l. Biochem Pharmacol. 2023 Mar;209:115418. doi: 10.1016/j.bcp.2023.115418. Epub 2023 Jan 21. Biochem Pharmacol. 2023. PMID: 36693437
Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.
Palmer JT, Axford LC, Barker S, Bennett JM, Blair M, Collins I, Davies DT, Ford L, Gannon CT, Lancett P, Logan A, Lunniss CJ, Morton CJ, Offermann DA, Pitt GR, Rao BN, Singh AK, Shukla T, Srivastava A, Stokes NR, Thomaides-Brears HB, Yadav A, Haydon DJ. Palmer JT, et al. Among authors: axford lc. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4215-22. doi: 10.1016/j.bmcl.2014.07.037. Epub 2014 Jul 19. Bioorg Med Chem Lett. 2014. PMID: 25086682
Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.
Gazzard L, Williams K, Chen H, Axford L, Blackwood E, Burton B, Chapman K, Crackett P, Drobnick J, Ellwood C, Epler J, Flagella M, Gancia E, Gill M, Goodacre S, Halladay J, Hewitt J, Hunt H, Kintz S, Lyssikatos J, Macleod C, Major S, Médard G, Narukulla R, Ramiscal J, Schmidt S, Seward E, Wiesmann C, Wu P, Yee S, Yen I, Malek S. Gazzard L, et al. Among authors: axford l. J Med Chem. 2015 Jun 25;58(12):5053-74. doi: 10.1021/acs.jmedchem.5b00464. Epub 2015 Jun 4. J Med Chem. 2015. PMID: 25988399
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.
Axford LC, Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ. Axford LC, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6598-603. doi: 10.1016/j.bmcl.2013.10.058. Epub 2013 Nov 4. Bioorg Med Chem Lett. 2013. PMID: 24239017