Abstract
RTI-113 [3beta-(4-chlorophenyl)tropan-2beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cocaine / administration & dosage*
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Cocaine / analogs & derivatives*
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Cocaine / pharmacology
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Dose-Response Relationship, Drug
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Extinction, Psychological
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Male
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Rats
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Rats, Inbred F344
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Reinforcement, Psychology
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Self Administration*
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Substance-Related Disorders / prevention & control*