Calcium signals often accompany mitosis. The most obvious example of calcium as a mitotic signal is at fertilization in vertebrate eggs, where the calcium transient induces anaphase onset. New imaging methods have demonstrated smaller calcium signals that control mitosis entry and mitosis exit in sea urchin embryos. Other experiments in mouse and frog embryos indicate that similar signals with similar function may play a part in these embryos, too. The links between these calcium control signals and mitotic kinase activation are adumbrated. It appears that calcium oscillations are a property of the mitotic state. A case is made that calcium may be a universal mitotic signal, with the possible exception of early meiotic events in oocytes.