Abstract
Recent studies have demonstrated the essential role of tumor necrosis factor alpha (TNF-alpha) in rheumatoid arthritis and Crohn's disease. This article discusses agents known to suppress the formation or activity of TNF-alpha, and summarizes clinical studies using anti-TNF-alpha antibodies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies / therapeutic use
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Arthritis, Rheumatoid / immunology
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Arthritis, Rheumatoid / therapy
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Crohn Disease / immunology
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Crohn Disease / therapy
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Humans
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Inflammation Mediators / antagonists & inhibitors*
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Inflammation Mediators / physiology
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Phosphodiesterase Inhibitors / pharmacology
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Sepsis / immunology
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Sepsis / therapy
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / physiology
Substances
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Antibodies
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Inflammation Mediators
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Phosphodiesterase Inhibitors
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Tumor Necrosis Factor-alpha