Inhibitors of endothelin

Med Res Rev. 1997 Jan;17(1):17-67. doi: 10.1002/(sici)1098-1128(199701)17:1<17::aid-med2>3.0.co;2-w.

Abstract

With the advent of the first generation of both selective and nonselective endothelin antagonists being a relatively recent event, the manifold therapeutic potentials of these compounds are only now being explored clinically. Undoubtedly, numerous clinical utilities for these compounds will soon be realized.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / drug therapy
  • Endothelin Receptor Antagonists
  • Endothelins / antagonists & inhibitors*
  • Endothelins / classification
  • Endothelins / genetics
  • Endothelins / metabolism
  • Endothelins / therapeutic use
  • Humans
  • Molecular Biology
  • Receptors, Endothelin / classification
  • Receptors, Endothelin / genetics
  • Receptors, Endothelin / metabolism
  • Signal Transduction
  • Tissue Distribution

Substances

  • Endothelin Receptor Antagonists
  • Endothelins
  • Receptors, Endothelin