The basic amino acid transporter (rBAT)-like immunoreactivity in paraventricular and supraoptic magnocellular neurons of the rat hypothalamus

S Hisano; H Haga; K Miyamoto; E Takeda; Y Fukui

doi:10.1016/0006-8993(95)01442-x

The basic amino acid transporter (rBAT)-like immunoreactivity in paraventricular and supraoptic magnocellular neurons of the rat hypothalamus

Brain Res. 1996 Feb 26;710(1-2):299-302. doi: 10.1016/0006-8993(95)01442-x.

Authors

S Hisano¹, H Haga, K Miyamoto, E Takeda, Y Fukui

Affiliation

¹ Department of Anatomy, School of Medicine, University of Tokushima, Japan.

PMID: 8963675
DOI: 10.1016/0006-8993(95)01442-x

Abstract

In the rat hypothalamus, the basic amino acid transporter (rBAT)-like immunoreactivity was analyzed by immunohistochemistry using an antibody against the 15-amino acid sequence of the deduced rat rBAT protein. In the supraoptic and the paraventricular nuclei, magnocellular neurons exhibited the marked rBAT-like immunoreactivity in intracellular structures but not in the plasma membrane. The results suggest that the rBAT serves as an intracellular amino acid transport system in magnocellular neurons.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Amino Acid Transport Systems
Animals
Biological Transport
Blotting, Western
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Hypothalamus / cytology
Hypothalamus / metabolism*
Immunohistochemistry
Male
Molecular Sequence Data
Neurons / metabolism*
Neurosecretory Systems / cytology
Neurosecretory Systems / metabolism*
Paraventricular Hypothalamic Nucleus / metabolism*
Peptide Fragments / genetics
Rats
Rats, Wistar

Substances

Amino Acid Transport Systems
Carrier Proteins
Peptide Fragments