Abstract
Evidence is rapidly accumulating that suggests that the growth and proliferation of pathogenic bacteria depend on proteolytic enzymes of the invading organism and of the host. Proteinase inhibitors targeting bacterial proteinases may be useful antimicrobial agents.
MeSH terms
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Animals
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Bacteria / enzymology*
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Bacteria / pathogenicity
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Bacterial Infections / drug therapy
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Bacterial Infections / microbiology
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Bacterial Proteins / drug effects
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Bacterial Proteins / physiology*
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Endopeptidases / drug effects
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Endopeptidases / physiology*
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Humans
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Kallikreins / metabolism
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Kinins / metabolism
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Protease Inhibitors / therapeutic use
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Virulence
Substances
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Bacterial Proteins
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Kinins
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Protease Inhibitors
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Endopeptidases
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Kallikreins